Chromophobe Renal Cell Carcinoma with Radiologic-Pathologic Correlation
| Autor: | Darcy J. Wolfman, Aaron M Udager, Jamie Marko, Andrew Nguyen, Ryan Craig |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Renal cortex Chromophobe Renal Cell Carcinoma Radiologic pathologic correlation Chromophobe cell Prognosis urologic and male genital diseases medicine.disease Kidney Neoplasms Vascularity medicine.anatomical_structure Genitourinary Imaging Renal cell carcinoma medicine Renal mass Humans Radiology Nuclear Medicine and imaging medicine.symptom business Carcinoma Renal Cell Clear cell |
| Zdroj: | Radiographics |
| ISSN: | 1527-1323 0271-5333 |
| DOI: | 10.1148/rg.2021200206 |
| Popis: | Renal cell carcinoma (RCC) is a heterogeneous group of neoplasms derived from the renal tubular epithelial cells. Chromophobe RCC (chRCC) is the third most common subtype of RCC, accounting for 5% of cases. chRCC may be detected as an incidental finding or less commonly may manifest with clinical symptoms. The mainstay of therapy for chRCC is surgical resection. chRCC has a better prognosis compared with the more common clear cell RCC. At gross pathologic analysis, chRCC is a solid well-defined mass with lobulated borders. Histologic findings vary by subtype but include large pale polygonal cells with abundant transparent cytoplasm, crinkled “raisinoid” nuclei with perinuclear halos, and prominent cell membranes. Pathologic analysis reveals only moderate vascularity. The most common imaging pattern is a predominantly solid renal mass with circumscribed margins and enhancement less than that of the renal cortex. The authors discuss chRCC with emphasis on correlative pathologic findings and illustrate the multimodality imaging appearances of chRCC by using cases from the Radiologic Pathology Archives of the American Institute for Radiologic Pathology. (©)RSNA, 2021 |
| Databáze: | OpenAIRE |
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