The influence of tumor oxygenation on (18)F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET)
| Autor: | Jurgen Seidel, Michael V. Green, Sebastien Hapdey, Stephen L. Bacharach, Linda W Chan, James B. Mitchell, Sean J. English, Anastasia L. Sowers, Murali C. Krishna, Joann Carson |
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| Přispěvatelé: | Radiation Oncology Branch, National Institutes of Health [Bethesda] (NIH)-National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Department of Nuclear Medicine, Breton, Céline |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Time Factors
MESH: Anoxia Pilot Projects 030218 nuclear medicine & medical imaging Mice 0302 clinical medicine MESH: Fluorodeoxyglucose F18 Neoplasms Medicine MESH: Animals MESH: Neoplasms Hypoxia Mice Inbred C3H medicine.diagnostic_test Deoxyglucose Air Temperature lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens MESH: Positron-Emission Tomography MESH: Temperature Oncology Positron emission tomography 030220 oncology & carcinogenesis Breathing Female medicine.symptom MESH: Oxygen lcsh:Medical physics. Medical radiology. Nuclear medicine lcsh:R895-920 [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine Carbohydrate metabolism lcsh:RC254-282 [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine 03 medical and health sciences Carbogen Fluorodeoxyglucose F18 Animals Radiology Nuclear Medicine and imaging MESH: Mice Inbred C3H MESH: Mice Models Statistical business.industry Research MESH: Time Factors Oxygenation Hypoxia (medical) Tumor Oxygenation MESH: Pilot Projects Oxygen MESH: Air Positron-Emission Tomography business Nuclear medicine MESH: Female MESH: Models Statistical |
| Zdroj: | Radiat Oncol Radiat Oncol, 2006, 1, pp.3. ⟨10.1186/1748-717X-1-3⟩ Radiation Oncology (London, England) Radiation Oncology, Vol 1, Iss 1, p 3 (2006) |
| Popis: | Background This study investigated whether changing a tumor's oxygenation would alter tumor metabolism, and thus uptake of 18F-FDG (fluorine-18 deoxyglucose), a marker for glucose metabolism using positron emission tomography (PET). Results Tumor-bearing mice (squamous cell carcinoma) maintained at 37°C were studied while breathing either normal air or carbogen (95% O2, 5% CO2), known to significantly oxygenate tumors. Tumor activity was measured within an automatically determined volume of interest (VOI). Activity was corrected for the arterial input function as estimated from image and blood-derived data. Tumor FDG uptake was initially evaluated for tumor-bearing animals breathing only air (2 animals) or only carbogen (2 animals). Subsequently, 5 animals were studied using two sequential 18F-FDG injections administered to the same tumor-bearing mouse, 60 min apart; the first injection on one gas (air or carbogen) and the second on the other gas. When examining the entire tumor VOI, there was no significant difference of 18F-FDG uptake between mice breathing either air or carbogen (i.e. air/carbogen ratio near unity). However, when only the highest 18F-FDG uptake regions of the tumor were considered (small VOIs), there was a modest (21%), but significant increase in the air/carbogen ratio suggesting that in these potentially most hypoxic regions of the tumor, 18F-FDG uptake and hence glucose metabolism, may be reduced by increasing tumor oxygenation. Conclusion Tumor 18F-FDG uptake may be reduced by increases in tumor oxygenation and thus may provide a means to further enhance 18F-FDG functional imaging. |
| Databáze: | OpenAIRE |
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