Architectural Insight into Inovirus-Associated Vectors (IAVs) and Development of IAV-Based Vaccines Inducing Humoral and Cellular Responses: Implications in HIV-1 Vaccines
| Autor: | Hassapis, K. A., Stylianou, Dora C., Kostrikis, Leontios G. |
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| Přispěvatelé: | Kostrikis, Leontios G. [0000-0002-5340-7109], Stylianou, Dora C. [0000-0003-4167-1380] |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Viral vectors
Inovirus Phage display HIV-1 vaccine lcsh:QR1-502 major histocompatibility antigen class 2 Human immunodeficiency virus 1 inovirus HIV Infections major histocompatibility antigen class 1 Review virus vector immunogenicity Inovirus display secondary immune response Epitope glycoprotein gp 41 lcsh:Microbiology immunology single stranded DNA binding protein virus glycoprotein bacteriophage phase 3 clinical trial (topic) humoral immunity animal genetics Antigen display CD8+ T lymphocyte virus replication AIDS Vaccines epitope Immunity Cellular biology melanoma antigen 1 Immunogenicity adenovirus vector neutralizing antibody polyclonal antibody capsid protein unclassified drug virology Vaccination Filamentous bacteriophage Infectious Diseases coat protein virus neutralization scanning transmission electron microscopy virus pathogenesis phage display viral vectors Genetic Vectors DNA sequence phase 1 clinical trial (topic) inovirus-associated vectors cellular immunity glycoprotein gp 120 Inovirus-associated vectors protein DNA binding chemistry T lymphocyte activation Viral vector Immunity Human immunodeficiency virus infection Virology gene vector Human immunodeficiency virus vaccine Humans Animals human protein structure transcription termination CD4+ T lymphocyte inoviridae vaccine nonhuman vasculotropin antibody and immunoglobulin production nucleotide sequence biology.organism_classification vaccination antigen display amino acid sequence Immunity Humoral inovirus display monoclonal antibody Human immunodeficiency virus antibody phase 2 clinical trial (topic) HIV-1 antigen expression immunological tolerance metabolism |
| Zdroj: | Viruses, Vol 6, Iss 12, Pp 5047-5076 (2014) Viruses |
| ISSN: | 1999-4915 |
| Popis: | Inovirus-associated vectors (IAVs) are engineered, non-lytic, filamentous bacteriophages that are assembled primarily from thousands of copies of the major coat protein gp8 and just five copies of each of the four minor coat proteins gp3, gp6, gp7 and gp9. Inovirus display studies have shown that the architecture of inoviruses makes all coat proteins of the inoviral particle accessible to the outside. This particular feature of IAVs allows foreign antigenic peptides to be displayed on the outer surface of the virion fused to its coat proteins and for more than two decades has been exploited in many applications including antibody or peptide display libraries, drug design, and vaccine development against infectious and non-infectious diseases. As vaccine carriers, IAVs have been shown to elicit both a cellular and humoral response against various pathogens through the display of antibody epitopes on their coat proteins. Despite their high immunogenicity, the goal of developing an effective vaccine against HIV-1 has not yet materialized. One possible limitation of previous efforts was the use of broadly neutralizing antibodies, which exhibited autoreactivity properties. In the past five years, however, new, more potent broadly neutralizing antibodies that do not exhibit autoreactivity properties have been isolated from HIV-1 infected individuals, suggesting that vaccination strategies aimed at producing such broadly neutralizing antibodies may confer protection against infection. The utilization of these new, broadly neutralizing antibodies in combination with the architectural traits of IAVs have driven the current developments in the design of an inovirus-based vaccine against HIV-1. This article reviews the applications of IAVs in vaccine development, with particular emphasis on the design of inoviral-based vaccines against HIV-1. © 2014 by the authors licensee MDPI, Basel, Switzerland. 6 5047 5076 |
| Databáze: | OpenAIRE |
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