Impact of a breathing-control system on target margins and normal-tissue sparing in the treatment of lung cancer: experience at the radiotherapy unit of Florence University
| Autor: | S. Cecchini, Isacco Desideri, Daniela Greto, Carla De Luca Cardillo, Silvia Bertocci, Benedetta Agresti, Giacomo Zei, Pieroluigi Bonomo, Vieri Scotti, Ciro Franzese, Mauro Loi, Icro Meattini, Livia Marrazzo, Gian Paolo Biti, Lorenzo Livi, Monica Mangoni, Calogero Saieva |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Lung Neoplasms medicine.medical_treatment Movement Treatment of lung cancer medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Neuroradiology Aged Aged 80 and over Lung medicine.diagnostic_test business.industry Respiration Ultrasound Interventional radiology Radiotherapy Dosage General Medicine Middle Aged medicine.disease Peripheral Tumor Burden Radiation therapy medicine.anatomical_structure Treatment Outcome Italy Female Radiotherapy Conformal business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | La Radiologia medica. 119(1) |
| ISSN: | 1826-6983 |
| Popis: | In lung cancer, a high radiation dose to the target area correlates with better local control but is frequently counterbalanced by a higher risk of lung toxicity. Several methods exist to coordinate respiratory motion in lung radiotherapy. We aimed to investigate the impact of a breathing-control system on irradiated volumes and dosimetric parameters in three-dimensional conformal radiotherapy (3D-CRT) and stereotactic radiotherapy (SRT) treatments. Twelve patients were scheduled for radical radiotherapy: five for SRT and seven for 3D-CRT. For each patient, in addition to the free-breathing computed tomography (CT) scan, four additional sets of CT slices were acquired using the Active Breathing Coordinator device (ABC, Elekta Oncology Systems Ltd., UK). The volumes acquired with the ABC device were significantly smaller than the free-breathing volumes [23 % reduction of planning tumour volume (PTV), p = 0.002]. ABC allowed a reduction of all dosimetric parameters [2.28 % reduction of percentage volume of lung treated to a dose of ≥20 Gy (V20), p = 0.004; 10 % reduction of mean lung dose (MLD), p = 0.009]. Significant differences were found both in SRT and in 3D-CRT, in peripheral and apical lesions. In our experience, ABC has the potential to reduce lung toxicity in the treatment of lung cancer; alternatively, it can allow the prescribed dose to be increased while maintaining the same risk of lung toxicity. |
| Databáze: | OpenAIRE |
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