Comparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis
| Autor: | Peter C. Appelbaum, Kim L. Credito, Lois M. Ednie |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Carbapenem
Imipenem Colony Count Microbial Microbial Sensitivity Tests Biology Meropenem Microbiology Bacteria Anaerobic chemistry.chemical_compound Minimum inhibitory concentration β lactams polycyclic compounds medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Doripenem biochemical phenomena metabolism and nutrition bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Carbapenems chemistry Susceptibility bacteria Ertapenem medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 52:365-373 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC50of 0.125 μg/ml and an MIC90of 1 μg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2× MIC after 48 h. |
| Databáze: | OpenAIRE |
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