Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs

Autor: Takayuki Yagi, Koichi Murata, Tomoko Ishii, Kaori Togashi, Yasufumi Asao, Masakazu Toi, Tsuyoshi Shiina, Kenichi Nagae, Masako Kataoka, Yoshiaki Matsumoto, Aya Yoshikawa, Naoyuki Murayama, Katsumi Ohira, Atsushi Otsuka, Yuusuke Tanaka, Susumu Saito, Hiroyuki Sekiguchi, Moritoshi Furu, Kenji Kabashima, Yoshiaki Sudo, Yoshihiro Ishida
Rok vydání: 2018
Předmět:
0301 basic medicine
media_common.quotation_subject
Posture
Field of view
Imaging phantom
General Biochemistry
Genetics and Molecular Biology
Photoacoustic Techniques
haemoglobin oxygen saturation
03 medical and health sciences
Optics
Imaging
Three-Dimensional
0302 clinical medicine
blood vessel
Computer Systems
Contrast (vision)
Humans
General Pharmacology
Toxicology and Pharmaceutics
030304 developmental biology
media_common
limb
Physics
0303 health sciences
Reproducibility
General Immunology and Microbiology
business.industry
Phantoms
Imaging
Lasers
Extremities
Articles
General Medicine
Viewing angle
Horizontal plane
optoacoustic
Visualization
laser
Wavelength
030104 developmental biology
motion pictures
030220 oncology & carcinogenesis
photoacoustic imaging
business
hemispherical detector array
Research Article
Zdroj: F1000Research
ISSN: 2046-1402
DOI: 10.12688/f1000research.16743.1
Popis: Background: A breast-specific photoacoustic imaging (PAI) system prototype equipped with a hemispherical detector array (HDA) has been reported as a promising system configuration for providing high morphological reproducibility for vascular structures in living bodies. Methods: To image the vasculature of human limbs, a newly designed PAI system prototype (PAI-05) with an HDA with a higher density sensor arrangement was developed. The basic device configuration mimicked that of a previously reported breast-specific PAI system. A new imaging table and a holding tray for imaging a subject's limb were adopted. Results: The device’s performance was verified using a phantom. Contrast of 8.5 was obtained at a depth of 2 cm, and the viewing angle reached up to 70 degrees, showing sufficient performance for limb imaging. An arbitrary wavelength was set, and a reasonable PA signal intensity dependent on the wavelength was obtained. To prove the concept of imaging human limbs, various parts of the subject were scanned. High-quality still images of a living human with a wider size than that previously reported were obtained by scanning within the horizontal plane and averaging the images. The maximum field of view (FOV) was 270 mm × 180 mm. Even in movie mode, one-shot 3D volumetric data were obtained in an FOV range of 20 mm in diameter, which is larger than values in previous reports. By continuously acquiring these images, we were able to produce motion pictures. Conclusion: We developed a PAI prototype system equipped with an HDA suitable for imaging limbs. As a result, the subject could be scanned over a wide range while in a more comfortable position, and high-quality still images and motion pictures could be obtained.
Databáze: OpenAIRE
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