Glycogen Phosphorylase Isoenzyme Bb, Myoglobin and BNP in ANT-Induced Cardiotoxicity
| Autor: | Zong-Xin Zhang, Jia-Yin Di, Shao-Jun Xin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Left ventricular ejection fraction Anthracycline QH301-705.5 medicine.medical_treatment Glycogen phosphorylase isoenzyme BB 030204 cardiovascular system & hematology Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Enzyme-linked immunosorbent assay Internal medicine medicine Anthracyclines cardiovascular diseases Biology (General) Combined diagnosis Cardiotoxicity Chemotherapy Ejection fraction General Immunology and Microbiology Myoglobin General Neuroscience Brain natriuretic peptide medicine.disease Leukemia 030220 oncology & carcinogenesis Cardiology cardiovascular system General Agricultural and Biological Sciences Isovolumic relaxation time Research Article |
| Zdroj: | Open Life Sciences Open Life Sciences, Vol 13, Iss 1, Pp 561-568 (2018) |
| ISSN: | 2391-5412 |
| Popis: | Anthracyline (ANT) has been demonstrated as a useful treatment for leukemia and solid tumors. However, ANT has previously reported cardiotoxic effects, which can reduce the therapeutic index for cancer treatment. This study aimed to investigate the associations of glycogen phosphorylase isoenzyme BB (GPBB), myoglobin (Mb), and brain natriuretic peptide (BNP) with anthracycline (ANT-induced cardiotoxicity (AIC)) amongst the Chinese population. Patients suffering from leukemia were recruited. Electrocardiogram and echocardiography were used along with chemotherapy to determine left ventricular ejection fraction (LVEF), mitral ratio of peak early to late diastolic filling velocity (E/A), E-wave deceleration time (EDT), and isovolumic relaxation time (IVRT). Double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) was employed to examine and compare serum GPBB, Mb, and BNP levels. Following chemotherapy, the patients presented higher levels of serum GPBB, Mb, and BNP than before chemotherapy treatment. The levels of LVEF (%), E/A, and IVRT were significantly decreased after chemotherapy, while EDT was markedly increased. The cumulative ANT dose was positively corelated to serum GPBB, Mb, and BNP levels while it was negatively corelated to LVEF levels. In conclusion, serum GPBB, Mb, and BNP levels in combination might provide higher diagnostic accuracy in the early detection of AIC compared with other single indicators. |
| Databáze: | OpenAIRE |
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