EFFECTS OF SODIUM HYALURONATE ON EPITHELIAL HEALING OF THE VESICAL MUCOSA AND VESICAL FIBROSIS IN RABBITS WITH ACETIC ACID INDUCED CYSTITIS
| Autor: | Katsuyuki Horie, Katsuya Takahashi, Yasuo Uchiyama, Toyomi Takahashi, Satoshi Miyauchi, Jun Takeuchi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology Sodium Urology Urinary Bladder Sodium hyaluronate chemistry.chemical_element Bladder capacity Epithelium Acetic acid chemistry.chemical_compound Animal model Fibrosis Cystitis Hyaluronic acid medicine Animals Hyaluronic Acid Acetic Acid Wound Healing Mucous Membrane Lagomorpha biology business.industry Organ Size Trypan Blue medicine.disease biology.organism_classification chemistry Rabbits business |
| Zdroj: | The Journal of Urology. :710-713 |
| ISSN: | 0022-5347 |
| Popis: | To evaluate the effect of sodium hyaluronate on epithelial healing of the vesical mucosa and vesical fibrosis, and clarify the effect of the sodium hyaluronate solution concentration, we administered sodium hyaluronate in the bladder of rabbits with acetic acid induced cystitis.Sodium hyaluronate at 3 concentrations (0.1%, 0.2% and 0.4%) was injected intravesically into rabbits with cystitis. Seven days after injection the effect of sodium hyaluronate was evaluated by bladder capacity measurement. Furthermore, the epithelial defective region of the mucosal membrane and bladder dry weight were determined and the condition of the epithelial membrane and extent of fibrosis were examined histologically.In all sodium hyaluronate treated groups a significant improvement in bladder capacity was observed compared to controls. In addition, a significant reduction was noted in the area of the epithelial defective region in the groups treated with 0.2% or 0.4% sodium hyaluronate and a significant decrease was noted in bladder dry weight in the group treated with 0.4% sodium hyaluronate. Histological examination revealed accelerated epithelial healing of the vesical mucosa and inhibited vesical fibrosis in the group treated with 0.4% sodium hyaluronate.Our findings suggest that sodium hyaluronate is effective for promoting epithelial healing of the vesical mucosa and inhibiting vesical fibrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|