Current practice patterns in nodal evaluation and adjuvant treatment of advanced stage endometrioid endometrial cancer: An SGO survey
Autor: | Jayanthi S. Lea, Jessica E. Parker, Jessica Lee, Salvatore Lococo, Matthew Carlson, David Miller |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Sentinel lymph node Gynecologic oncology Lymph node evaluation lcsh:Gynecology and obstetrics lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Survey Article Endometrial cancer Internal medicine medicine Adjuvant therapy Stage (cooking) Radiation treatment planning lcsh:RG1-991 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Adjuvant treatment lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 030220 oncology & carcinogenesis Electronic data Lymphadenectomy business |
Zdroj: | Gynecologic Oncology Reports Gynecologic Oncology Reports, Vol 34, Iss, Pp 100620-(2020) |
ISSN: | 2352-5789 |
Popis: | Highlights • The majority of respondents evaluate lymph nodes via sentinel lymph node mapping for grade 1–2 endometrial cancer. • Only 50% of respondents perform intraoperative sentinel lymph node mapping for grade 3 endometrial cancer. • 90% of respondents give chemotherapy-based adjuvant treatment for advanced endometrial cancer. • 75% of respondents combine radiation therapy with chemotherapy in stage III endometrial cancer. The use of sentinel lymph node (SLN) mapping over full lymphadenectomy for endometrioid endometrial cancer (EC) has had varying uptake. Adjuvant therapy for advanced stage EC is also a debated topic globally. Two recent randomized controlled trials have attempted to clarify which treatment approach should be recommended. Our aims were to identify common practice patterns in the intraoperative lymph node evaluation as well as the practice patterns in the treatment of advanced stage (stage III-IV) endometrioid EC among gynecologic oncologists. A 16-question survey was distributed via email to all Society of Gynecologic Oncology members. Study data were collected anonymously and managed using REDCap electronic data tools. Respondents were asked questions regarding demographics, assessing nodal status, and choice of adjuvant treatment for each stage. Descriptive statistics, student’s t-tests, and chi-squared analyses were performed. A total of 1531 surveys were distributed and 187 (12%) members responded. The majority (70%) of respondents identified nodal metastases by performing SLN mapping prior to nodal evaluation in grade 1–2 disease, however only half perform SLN mapping in grade 3 EC. Adjuvant chemotherapy was recommended by 90% of practitioners for advanced EC. However, external beam radiation or brachytherapy was combined with chemotherapy in 74% of stage III EC and 35% of stage IV EC. While 90% of practitioners recommend chemotherapy-based adjuvant treatment for women with stage IIIA–IVA endometrioid EC, decreasing local recurrence appears to be a factor in treatment planning as radiation combined with chemotherapy is used in 63% of cases. |
Databáze: | OpenAIRE |
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