Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation

Autor: Bomee Chung, Alexander Jaschke, Deike Hesse, Annette Schürmann
Rok vydání: 2012
Předmět:
ARFRP1
ADP-ribosylation factor related protein 1
Lipid Metabolism Disorder
lcsh:Life
lcsh:QR1-502
Lipid Metabolism Disorders
Golgi Apparatus
Review Article
Apo B
apolipoprotein B
Endoplasmic Reticulum
Biochemistry
Autoantigens
lcsh:Microbiology
MGAT
monoacylglycerol acyltransferase
Mice
PAT
perilipin
ADRP and Tip47
Lipid droplet
Chylomicrons
Protein Interaction Mapping
ADP-ribosylation factor-like 1 (ARL1)
Adipocytes
MAG
monoacylglycerol
PCTV
pre-chylomicron transport vesicle
ADP-Ribosylation Factors
COPII
coating protein II
lipids (amino acids
peptides
and proteins)
DGAT
diacylglycerol acyltransferase
SNAP-23
synaptosome-associated protein of 23 kDa
MTP
microsomal triacylglycerol transfer protein
HSL
hormone-sensitive lipase
Chylomicron retention disease
ADP-ribosylation factor related protein 1 (ARFRP1)
LD
lipid droplet
NSF
N-ethylmaleimide-sensitive factor
TAG
triacylglycerol
Lipolysis
Biophysics
ATGL
adipose triacylglycerol lipase
Biology
ABHD5
abhydrolase domain containing 5
S2
ARL1
ADP-ribosylation factor-like 1
ER
endoplasmic reticulum
GRIP
Golgin-97
RanBP2α
Imhp1 and p230/Golgin-245
medicine
Animals
Humans
Molecular Biology
GTPase
GPCR
G-protein-coupled receptor
SNARE
SNAP receptors
FABP
fatty-acid-binding protein
ADRP
adipocyte differentiation-related protein
Golgi Matrix Proteins
Membrane Proteins
VLDL
very-low-density lipoprotein
Lipid metabolism
Biological Transport
Cell Biology
medicine.disease
Lipid Metabolism
Tip47
47 kDa tail-interacting protein
Rab
VAMP
vesicle-associated membrane protein
lcsh:QH501-531
Membrane protein
siRNA
small interfering RNA
trans-Golgi
pCM
pre-chylomicrons
SNAP
soluble NSF attachment protein
DAG
diacylglycerol
Lipoprotein
Chylomicron
Golgin
Zdroj: Bioscience Reports
Bioscience Reports, Vol 33, Iss 1, p e00001 (2012)
ISSN: 1573-4935
Popis: LDs (lipid droplets) carrying TAG (triacylglycerol) and cholesteryl esters are emerging as dynamic cellular organelles that are generated in nearly every cell. They play a key role in lipid and membrane homoeostasis. Abnormal LD dynamics are associated with the pathophysiology of many metabolic diseases, such as obesity, diabetes, atherosclerosis, fatty liver and even cancer. Chylomicrons, stable droplets also consisting of TAG and cholesterol are generated in the intestinal epithelium to transport exogenous (dietary) lipids after meals from the small intestine to tissues for degradation. Defective chylomicron formation is responsible for inherited lipoprotein deficiencies, including abetalipoproteinaemia, hypobetalipoproteinaemia and chylomicron retention disease. These are disorders sharing characteristics such as fat malabsorption, low levels of circulating lipids and fat-soluble vitamins, failure to thrive in early childhood, ataxic neuropathy and visual impairment. Thus understanding the molecular mechanisms governing the dynamics of LDs and chylomicrons, namely, their biogenesis, growth, maintenance and degradation, will not only clarify their molecular role, but might also provide additional indications to treatment of metabolic diseases. In this review, we highlight the role of two small GTPases [ARFRP1 (ADP-ribosylation factor related protein 1) and ARL1 (ADP-ribosylation factor-like 1)] and their downstream targets acting on the trans-Golgi (Golgins and Rab proteins) on LD and chylomicron formation.
Databáze: OpenAIRE
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