Amino acids and peptides. XIII. Synthetic studies on N-terminal tripeptide amide analogs of fibrin .ALPHA.-chain
| Autor: | Toshiki Tsuji, Katsuhiko Hirase, Yoshinori Imoto, Masanori Miyano, Masahiro Iwamoto, Koichi Kawasaki |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.drug_class
Stereochemistry Molecular Sequence Data Carboxamide Tripeptide Fibrin chemistry.chemical_compound Thrombin Amide Drug Discovery medicine Peptide synthesis Amino Acid Sequence Peptide sequence chemistry.chemical_classification biology General Chemistry General Medicine Amino acid Biochemistry chemistry biology.protein Peptides circulatory and respiratory physiology medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 39:584-589 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | N-Terminal tripeptide analogs of fibrin alpha-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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