Measurement of plasma placental proteins and estriol in the detection of intrauterine growth retardation
| Autor: | Andrew D. Nisbet, R.G. Sutcliffe, C. H. W. Horne, N. Cruickshank, V. Jandial, Roy D. Bremner |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Pregnancy-associated plasma protein A Single sample Pregnancy Proteins Pregnancy Internal medicine medicine Humans Pregnancy-Associated Plasma Protein-A Placental lactogen reproductive and urinary physiology Ultrasonography Fetal Growth Retardation Growth retardation medicine.diagnostic_test Estriol business.industry Pregnancy-Specific beta 1-Glycoproteins Obstetrics and Gynecology Placental Lactogen medicine.disease Endocrinology Reproductive Medicine Immunoassay Female Placental Proteins business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 13:333-342 |
| ISSN: | 0301-2115 |
| Popis: | This study was designed as an assessment of the clinical value of total estriol, placental lactogen (hPL), pregnancy specific glycoprotein (SP1), pregnancy-associated plasma protein-A (PAPP-A) and placental protein 5 (PP5), measured in a single sample of maternal serum, in the detection of intrauterine growth retardation (IUGR) in a large series of high risk pregnancies. Our results show the highest detection rate with SP1 (51%) and second highest with hPL (35%); estriol was less useful while PAPP-A and PP5 were of no value. However, there were 31% of false positives with SP1 compared with 14% for hPL. The best combination of the five parameters for the diagnosis of IUGR was achieved by measurement of both SP1 and hPL, with a low concentration of either protein indicating IUGR (sensitivity 63%, specificity 63%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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