Getting into Position: Nuclear Movement in Muscle Cells
| Autor: | Mary K. Baylies, Mafalda Azevedo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Muscle size
Movement LINC complex Cell Biology Article 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Myocyte Muscle Skeletal Cytoskeleton Process (anatomy) 030304 developmental biology Cell Nucleus Muscle Cells 0303 health sciences Skeletal muscle Cell Biology Drosophila melanogaster medicine.anatomical_structure Neuroscience 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Trends Cell Biol |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2020.01.002 |
| Popis: | The positioning of nuclei within the cell is a dynamic process that depends on the cell’s fate and developmental stage and that is adjusted for optimal cell function. This is especially true in skeletal muscle cells, which contain hundreds of myonuclei distributed evenly along the periphery of the muscle cell. Mispositioned myonuclei are often associated with muscle dysfunction and disease. Different mechanisms governing myonuclear positioning are now emerging, with several of the new genes implicated in nuclear movement linked to human muscle disease. Here we discuss the recent advances in myonuclear positioning and its implications for muscle size and function from the view of Drosophila. Additionally, we highlight similarities and differences to mammalian systems and provide connections to human muscle disease. |
| Databáze: | OpenAIRE |
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