Investigation of the optimal duration of bed rest in the supine position to reduce complications after lumbar puncture combined with intrathecal chemotherapy: a multicenter prospective randomized controlled trial
| Autor: | Xiaozhe Li, Meilan Chen, Duo-Rong Xu, Juan Li, Junru Liu, Zhenhai Zhou, Xiuzhen Tong, Beihui Huang, Lifen Kuang |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Supine position medicine.medical_treatment Bed rest Spinal Puncture law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Lumbar puncture Supine Position Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Complications after intrathecal chemotherapy Injections Spinal medicine.diagnostic_test business.industry Incidence (epidemiology) Clinical trial Oncology Anesthesia Original Article Bed rest time Female Tolerance to long-term bed rest business 030217 neurology & neurosurgery Bed Rest |
| Zdroj: | Supportive Care in Cancer |
| ISSN: | 1433-7339 0941-4355 1701-1671 |
| Popis: | Purpose This randomized, open-label trial was conducted to investigate the optimal duration of bed rest after intrathecal chemotherapy to reduce the incidence of complications without increasing patients’ tolerance to long-term bed rest. Methods A total of 390 patients receiving intrathecal chemotherapy were randomly assigned 1:1:1 to undergo bed rest for 6, 8, or 10 h after intrathecal chemotherapy. The primary outcome was the rate of complications after intrathecal chemotherapy. The analysis was per protocol. Results A total of 359 patients among the 390 patients in our study completed follow-up with 120 patients in the 6-h group, 120 in the 8-h group, and 119 in the 10-h group. The complications among the three groups differed significantly (P = 0.005). The 6-h group had significantly more complications than the 8- (50, 41.7% vs 29, 24.2%, P = 0.004) and 10-h groups (50, 41.7% vs 31, 26.1%, P = 0.011), whereas the difference between the 8- and 10-h groups was not significant (29, 24.2% vs 31, 26.1%, P = 0.737). Conclusions The overall results support that the optimal time interval for bed rest in the supine position after intrathecal chemotherapy is 8 h. This trial is registered with the Chinese Clinical Trial Registry (number ChiCTR-IOR-17011671). |
| Databáze: | OpenAIRE |
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