Comparison Between Intravenous Nalbuphine and Lidocaine in Reducing Propofol-Induced Injection Pain During Gastroscopy: A Randomized Controlled Trial

Autor:	Cuiyu Xie, Yao Lu, Jiang Wang, Jinjuan Duan, Yongqi Yu
Rok vydání:	2020
Předmět:	Bradycardia Lidocaine medicine.medical_treatment Nalbuphine Hypoxemia law.invention Randomized controlled trial law Anesthesiology Gastroscopy medicine RD78.3-87.3 Adverse effect Propofol injection pain Saline Original Research business.industry Anesthesiology and Pain Medicine Anesthesia Neurology (clinical) medicine.symptom Propofol business medicine.drug
Zdroj:	Pain and Therapy Pain and Therapy, Vol 9, Iss 2, Pp 563-571 (2020)
ISSN:	2193-8237
Popis:	Introduction Intravenous propofol anesthesia is widely used in painless endoscopy. However, propofol injection pain is a common adverse effect. This study investigated the effects of nalbuphine and lidocaine in reducing propofol-induced injection pain. Methods In this double-blind, randomized study, 330 patients were randomly divided into three groups by using a random number table: the nalbuphine group (N), lidocaine group (L), and control group (C). The N, L, and C groups received either 0.1 mg/kg nalbuphine, 0.5 mg/kg lidocaine, or an equivalent volume of normal saline, respectively, as pretreatment drug. Then propofol was manually injected. The primary outcome of this study was the incidence of propofol-induced injection pain, and secondary outcomes included the severity of propofol-induced injection pain, vital signs, and adverse events, including hypotension, bradycardia (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad2aec900a6665c2e43b2e7355a7984 https://pubmed.ncbi.nlm.nih.gov/32748184 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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