Nanostructured Coating for Biomaterial Lubrication through Biomacromolecular Recruitment
| Autor: | Chengxiong Lin, Hongping Wan, Xinghong Zhao, Hans J. Kaper, Prashant K. Sharma |
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| Přispěvatelé: | Man, Biomaterials and Microbes (MBM), Personalized Healthcare Technology (PHT) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cartilage
Articular glycoprotein Materials science ADSORPTION Dopamine Shear force FRICTION TRAUMA 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences RESTORE biomacromolecules BIOLUBRICATION Coating Coated Materials Biocompatible CARTILAGE Adhesives Lubrication Synovial Fluid Synovial fluid Animals General Materials Science Polylysine Composite material Hyaluronic Acid POLYCARBONATE URETHANES LUBRICIN SURFACES Biomaterial HYALURONIC-ACID Quartz crystal microbalance 021001 nanoscience & nanotechnology polymeric 0104 chemical sciences engineering Cattle Proteoglycans Adhesive ADHESIVE 0210 nano-technology Layer (electronics) nanostructured coating Research Article biolubrication system |
| Zdroj: | ACS Applied Materials & Interfaces ACS Applied Materials & Interfaces, 12(21), 23726-23736. AMER CHEMICAL SOC |
| ISSN: | 1944-8244 |
| DOI: | 10.1021/acsami.0c04899 |
| Popis: | Biomaterials employed in the articular joint cavity, such as polycarbonate urethane (PCU) for meniscus replacement, lack of lubrication ability, leading to pain and tissue degradation. We present a nanostructured adhesive coating based on dopamine-modified hyaluronan (HADN) and poly-lysine (PLL), which can reestablish boundary lubrication between the cartilage and biomaterial. Lubrication restoration takes place without the need of exogenous lubricious molecules but through a novel strategy of recruitment of native lubricious molecules present in the surrounding milieu. The biomimetic adhesive coating PLL-HADN (78 nm thickness) shows a high adhesive strength (0.51 MPa) to PCU and a high synovial fluid responsiveness. The quartz crystal microbalance with dissipation monitoring shows the formation of a thick and softer layer when these coatings are brought in contact with the synovial fluid. X-ray photoelectron spectroscopy and ConA-Alexa staining show clear signs of lubricious protein (PRG4) recruitment on the PLL-HADN surface. Effective recruitment of a lubricious protein by PLL-HADN caused it to dissipate only one-third of the frictional energy as compared to bare PCU when rubbed against the cartilage. Histology shows that this reduction makes the PLL-HADN highly chondroprotective, whereas PLL-HA coatings still show signs of cartilage wear. Shear forces in the range of 0.07-0.1 N were able to remove âˆ80% of the PRG4 from the PCU-PLL-HA but only 27% from the PCU-PLL-HADN. Thus, in this study, we have shown that surface recruitment and strong adsorption of biomacromolecules from the surrounding milieu is an effective biomaterial lubrication strategy. This opens up new possibilities for lubrication system reconstruction for medical devices. |
| Databáze: | OpenAIRE |
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