Development and characterization of pH responsive polymeric nanoparticles of SN-38 for colon cancer
| Autor: | Shilpi Prasad, J. S. Dangi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Kinetics Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) SN-38 02 engineering and technology Pharmacology Irinotecan 030226 pharmacology & pharmacy Chitosan 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Irinotecan Hydrochloride medicine Humans Drug Carriers General Medicine Prodrug Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Polyelectrolyte chemistry Colonic Neoplasms Nanoparticles Camptothecin 0210 nano-technology Drug carrier Biotechnology Nuclear chemistry medicine.drug |
| Zdroj: | Artificial cells, nanomedicine, and biotechnology. 44(8) |
| ISSN: | 2169-141X |
| Popis: | 7-Ethyl-10-hydroxycamptothecin (SN-38) is 1000 times more cytotoxic than its prodrug Irinotecan hydrochloride (CPT-11). It is not used therapeutically because of its insolubility in acceptable solvents. The objective of the present study was to prepare chitosan nanoparticles (CsENP) of SN-38 by polyelectrolyte complexation method using the Box-Behnken design. CsENPs were evaluated for mean particle size, drug loading, entrapment efficiency and characterized by TEM, XRD, DSC and FTIR. The actual values represented good agreement with predicted values. Drug release behavior in simulated colonic fluid followed Higuchi kinetics. CsENPs were stable and can be used further for treatment of colon cancer by oral route. |
| Databáze: | OpenAIRE |
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