Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

Autor: Jiao Xiao, Daichao Wu, Yan Li, Yukun Li, Gui-fang Luo, Yan Ma, Chang-ye Chen
Rok vydání: 2018
Předmět:
0301 basic medicine
Infertility
medicine.medical_specialty
endocrine system diseases
Disease
030226 pharmacology & pharmacy
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Internal medicine
medicine
Hyperinsulinemia
Animals
Humans
Obesity
General Pharmacology
Toxicology and Pharmaceutics
business.industry
Polycystic ovary syndrome (PCOS)
Female infertility
Ovary
nutritional and metabolic diseases
General Medicine
Luteinizing Hormone
medicine.disease
Polycystic ovary
female genital diseases and pregnancy complications
Metformin
030104 developmental biology
Endocrinology
Cardiovascular Diseases
Female
Follicle Stimulating Hormone
Insulin Resistance
business
Hyperandrogenism
Infertility
Female
medicine.drug
Polycystic Ovary Syndrome
Zdroj: Life sciences. 228
ISSN: 1879-0631
Popis: Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis (HPOA) function disorders. This syndrome results in hyperandrogenemia (HA), hyperinsulinemia/insulin resistance (IR), increased estrone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ratio imbalance, infertility, cardiovascular diseases, endometrial dysfunction, obesity, and including a litany of other health issues. Furthermore, PCOS has been garnered in recent times. Interventions like metformin, orlistat, hormonal contraceptives, GLP1 agonists, and VitD have been applied to ameliorate or reverse the pathological characterization of PCOS. Moreover, drug-combined therapy of PCOS is superior to single drug administration. This review will focus on the recent progress in pathogenesis and therapy of PCOS.
Databáze: OpenAIRE
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