Rice (Oryza sativa japonica) albumin hydrolysates suppress postprandial blood glucose elevation by adsorbing glucose and inhibiting Na+-d-glucose cotransporter SGLT1 expression
| Autor: | Hitoshi Kumagai, Shigenobu Ina, Hanae Nakamura, Yusuke Yamaguchi, Aya Hamada, Hitomi Kumagai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Rice protein animal structures endocrine system diseases Rice albumin peptides Medicine (miscellaneous) Hydrolysate 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology D-Glucose Internal medicine Diabetes mellitus medicine Blood glucose TX341-641 030109 nutrition & dietetics Nutrition and Dietetics Nutrition. Foods and food supply Albumin Glucose adsorption SGLT1 expression 04 agricultural and veterinary sciences Oral glucose tolerance tests Trypsin medicine.disease 040401 food science In vitro Endocrinology Postprandial chemistry Cotransporter Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 64, Iss, Pp 103603-(2020) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2019.103603 |
| Popis: | The mechanism of the suppressive effect of rice albumin (RA) on postprandial hyperglycemia after glucose loading was investigated. In order to examine if small peptides derived from RA are responsible for prevention of postprandial hyperglycemia, RA was hydrolysed to indigestible high-molecular-weight peptides (HMP) and low-molecular-weight peptides (LMP) by trypsin, HMP and LMP being fractionated by gel-filtration chromatography. In oral glucose tolerance test (OGTT), both HMP and LMP suppressed the increase in blood glucose levels. In vitro diffusion test results showed that HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. On the other hand, LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1) in STC-1 cells. Therefore, the suppressive effect of RA on postprandial hyperglycemia would be due to the dual actions of HMP and LMP. Our results demonstrated the potential use of RA as a functional food material to prevent diabetes. |
| Databáze: | OpenAIRE |
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