Supplementation with branched-chain amino acids ameliorates hypoalbuminemia, prevents sarcopenia, and reduces fat accumulation in the skeletal muscles of patients with liver cirrhosis
| Autor: | Yuichiro Eguchi, Hirokazu Takahashi, Kenichi Tanaka, Yoichiro Kitajima, Seiji Kawazoe, Naofumi Ono, Kenichiro Murayama, Shinji Iwane, Takahisa Eguchi, Keizo Anzai, Takuya Kuwashiro, Takumi Akiyama |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Liver Cirrhosis Male medicine.medical_specialty Sarcopenia Cirrhosis Tomography Scanners X-Ray Computed Adipose tissue Kaplan-Meier Estimate Carbohydrate metabolism Statistics Nonparametric Body Mass Index 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Humans Hypoalbuminemia Longitudinal Studies Muscle Skeletal Serum Albumin Aged Aged 80 and over business.industry Gastroenterology Skeletal muscle Hepatology Middle Aged medicine.disease Prognosis Survival Rate Endocrinology medicine.anatomical_structure Adipose Tissue 030220 oncology & carcinogenesis Concomitant Dietary Supplements 030211 gastroenterology & hepatology Female business Amino Acids Branched-Chain |
| Zdroj: | Journal of gastroenterology. 53(3) |
| ISSN: | 1435-5922 |
| Popis: | Liver cirrhosis induces marked metabolic disorders, protein-energy malnutrition, and sarcopenia. The objective of the study reported here was to investigate the effects of dietary branched-chain amino acids (BCAAs) on systemic glucose metabolism, skeletal muscle, and prognosis of patients with liver cirrhosis. Japanese patients with liver cirrhosis (n = 21) were enrolled into a longitudinal study in which their diets were supplemented with BCAAs. We evaluated glucose metabolism and analyzed the skeletal muscle area index (SAI) and intramuscular adipose tissue content (IMAC) using computed tomography. After 48 weeks of supplementation with BCAAs, there were no changes in glucose metabolism and skeletal muscle findings. In patients with ameliorated hypoalbuminemia, IMAC was significantly decreased and SAI was preserved concomitant with decreasing 90- and 120-min post-challenge plasma glucose levels (P |
| Databáze: | OpenAIRE |
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