Impact of calcification on percutaneous coronary intervention: MACE‐Trial 1‐year results
| Autor: | Jeffrey J. Popma, Ryan W. Bolduan, Roxana Mehran, Talhat Azemi, Gregory R. Giugliano, Samin K. Sharma, Jon R. Resar, Manesh R. Patel, Brad J. Martinsen, Ron Waksman, David Cohen |
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| Rok vydání: | 2019 |
| Předmět: |
Atherectomy
Coronary Male medicine.medical_specialty Time Factors medicine.medical_treatment Coronary Artery Disease 030204 cardiovascular system & hematology Severity of Illness Index Lesion Atherectomy 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Risk Factors Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies 030212 general & internal medicine Vascular Calcification Prospective cohort study Aged Aged 80 and over business.industry Percutaneous coronary intervention Retrospective cohort study General Medicine Middle Aged medicine.disease United States Clinical trial Treatment Outcome Female medicine.symptom Cardiology and Cardiovascular Medicine business Mace Calcification |
| Zdroj: | Catheterization and Cardiovascular Interventions. 94:187-194 |
| ISSN: | 1522-726X 1522-1946 0193-0214 |
| Popis: | OBJECTIVES The Multi-center Prospective Study to Evaluate Outcomes of Moderate to Severely Calcified Coronary Lesions (MACE-Trial) was designed to provide further insight on the impact of calcification on procedural and long-term percutaneous coronary intervention outcomes. BACKGROUND Prior studies evaluating the impact of lesion calcification on percutaneous coronary intervention outcomes are limited by: retrospective nature, pooled data from multiple studies, or lack of specificity around calcification with only operator assessment and without core lab evaluation. METHODS The MACE-Trial was a prospective, multicenter, observational clinical study that enrolled 350 subjects at 33 sites from September 2013 to September 2015. Core lab assessed subject stratification by lesion calcification (none/mild [N = 133], moderate [N = 99], and severe [N = 114]). Endpoints were lesion success, procedural success, and 1-year major adverse cardiac events (MACEs). RESULTS Presence of severe calcification had significant impact on lesion success ([83.3%] versus none/mild calcification [94.7%, P = 0.006]) and procedural success ([86.8%] versus moderate [95.0%, P = 0.028], and none/mild [97.7%, P = 0.001]). 1-year MACE rates were associated with presence of calcification in subjects with none/mild (4.7%), moderate (8.7%), and severe (24.4%) (P |
| Databáze: | OpenAIRE |
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