Evaluation of antioxidant and anticancer activities of chemical constituents of the Saururus chinensis root extracts
| Autor: | Anis Ahamed, Radhakrishnan Surendra Kumar, Akbar Idhayadhulla, Abdullah Alaklabi, Ibrahim A. Arif |
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| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
DPPH medicine.medical_treatment Flavonoid Ethyl acetate 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Food science Hydrogen peroxide lcsh:QH301-705.5 chemistry.chemical_classification ABTS Ethanol Agricultural and Biological Sciences(all) 010405 organic chemistry Ferric reducing ability of plasma 0104 chemical sciences lcsh:Biology (General) chemistry Biochemistry 030220 oncology & carcinogenesis General Agricultural and Biological Sciences |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 25, Iss 7, Pp 1387-1392 (2018) |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2016.12.021 |
| Popis: | Evaluation of antioxidant and anticancer activities were screened by various Saururus chinensis root extracts. Four solvents (ethyl acetate, methanol, ethanol, and water) extracts were investigated for their total flavonoids, phenol contents and their antioxidant activity of DPPH (2,2-diphenyl-1-picrylhydrazyl), NO (nitric oxide), H2O2 (hydrogen peroxide), ABTS 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid)diammonium assays, FRAP (ferric reducing ability of plasma) assays and anticancer activity. The total phenolic and flavonoid content of extracts were determined by using FC (Folin–Ciocalteu) and AlCl3 colorimetric assay method. Total flavonoid content in these plants ranged from 24.7 to 72.1 mg g−1 and amount of free phenolic compounds was between 11.2 and 67.1 mg g−1 extract. The all extracts have significant levels of phenolics and flavonoids content. Anticancer activity was screened for MCF-7 breast cancer cell line. Ethanol extract shows significant of antioxidant activity and water extract shows significant of anticancer activity compared with standard (BHT) butylated hydroxy toluene. These ethanol and water extracts could be considered as a natural source for using antioxidant, and anticancer agents compared to commercial available synthetic drugs. Keywords: Saururus chinensis root, Solvent extracts, Antioxidant activity, Anticancer activity |
| Databáze: | OpenAIRE |
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