Non-Hodgkin's lymphoma of the testis: a retrospective study of 84 patients treated in the French anticancer centres
| Autor: | P. Biron, J. D'Anjou, Ch. Chevreau, Jean-Léon Lagrange, V. Beckendorf, A. Delobel-Deroide, J. Merrier, J. Dumont, P. Chinet-Charrot, A. Ramaioli, J.-M. Karsenty, R.-M. Parache, Ch. Theodore, M.J. Terrier-Lacombe, C. Chassagne, J.P. Droz |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Testicular Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Prospective cohort study Aged Neoplasm Staging Retrospective Studies Aged 80 and over Chemotherapy Radiotherapy business.industry Lymphoma Non-Hodgkin Retrospective cohort study Hematology Middle Aged medicine.disease Prognosis Chemotherapy regimen Combined Modality Therapy Survival Analysis Surgery Lymphoma Non-Hodgkin's lymphoma Oncology Chemotherapy Adjuvant Neoplasm Recurrence Local business Diffuse large B-cell lymphoma Orchiectomy |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 12(9) |
| ISSN: | 0923-7534 |
| Popis: | Primary non-Hodgkin's lymphoma of the testicle is rare. We analysed cases treated in French anticancer centres from 1969 to 1995. All cases were reviewed and classified according to the R.E.A.L. Classification. Eighty-four cases were included in this study. The median age was 67 years (17-85). Disease was classified as stages I in 42 cases, stages II in 19 and stages III-IV in 23. Diffuse large B-cell lymphoma was diagnosed in 75% of cases. Treatment included orchidectomy and radiotherapy and/or chemotherapy. A complete response was obtained in 72.6% of the patient population and in 100%, 68% and 33% of stage I, II and III-IV disease respectively. Recurrence occurred in 32 cases and the most frequent site was the central nervous system: six of these patients presented stage I disease. Median overall survival was 32 months for the entire population, 52 months for stage I, 32 months for stage II, and 12 months for stage III-IV cases (P < 0.0001). Among patients presenting stage I disease, no difference was found between those treated with combined surgery and chemotherapy or surgery followed or not followed by radiotherapy. This study confirms that non-Hodgkin's lymphoma of the testicle carries a poor prognosis. Systemic adjuvant chemotherapy should be discussed because of the high recurrence rate. Inclusion of these cases in large co-operative prospective studies is recommended. |
| Databáze: | OpenAIRE |
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