A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV
| Autor: | Michael J. Boivin, Sujal M. Parikh, Robert O. Opoka, Rachelle A. Busman, Bruno Giordani, Connie Page, Paul Bangirana |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Adolescent Population HIV Infections Pilot Projects Neuropsychological Tests Antiretroviral Therapy Highly Active medicine Humans Uganda Cognitive rehabilitation therapy Child education Problem Solving education.field_of_study medicine.diagnostic_test Kaufman Assessment Battery for Children Cognitive disorder Neuropsychology Neuropsychological test medicine.disease Treatment Outcome Neuropsychology and Physiological Psychology Cognitive remediation therapy Therapy Computer-Assisted Female Cognition Disorders Psychology Neurocognitive Computer-Assisted Instruction Clinical psychology |
| Zdroj: | Neuropsychology. 24:667-673 |
| ISSN: | 1931-1559 0894-4105 |
| Popis: | OBJECTIVE: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. METHOD: Sixty Ugandan children with HIV (23 on ART) were randomly assigned to 10 sessions of Captains Log CCRT (Sandford 2007) training configured for attention and memory skills or no intervention. Kaufman Assessment Battery for Children (2nd ed. KABC-2; Kaufman & Kaufman 2004) performance at baseline indicated pervasive neurocognitive impairment. Cognitive ability was assessed before and after training using the Cogstate computerized neuropsychological test (Darby Maruff Collie & McStephen 2002). Viral load along with CD4 and CD8 absolute and activation levels also were measured posttest. RESULTS: CCRT was well received with a 95% adherence rate to scheduled training sessions. CCRT intervention children showed greater improvement on a Cogstate card detection task of simple attention (p = .02) and speed of correct moves on a Groton Maze Learning Task (p < .001). These analyses were completed using an analysis of covariance model that adjusted Cogstate performance for the childs age standardized weight for age gender socioeconomic status school grade level and baseline KABC-2 performance. ART treatment was not related to Cogstate performance or improvement as a result of CCRT. CD4 and CD8 activation levels were correlated with Cogstate improvement specifically for the CCRT group. CONCLUSIONS: CCRT was feasible with our study population and improved maze learning and attention on a detection task. This supports previous findings by our group with cerebral malaria survivors (Bangirana Giordani et al. 2009). Copyright 2010 APA all rights reserved. |
| Databáze: | OpenAIRE |
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