Down-Regulation of Cannabinoid Type 1 (CB1) Receptor and its Downstream Signaling Pathways in Metastatic Colorectal Cancer
| Autor: | Nicola Veronese, Valentina De Nunzio, Maria Gabriella Caruso, Dionigi Lorusso, Isabella Gigante, Valeria Tutino, Gianluigi Giannelli, Maria Notarnicola |
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| Přispěvatelé: | Tutino, V., Caruso, M.G., De Nunzio, V., Lorusso, D., Veronese, N., Gigante, I., Notarnicola, M., Giannelli, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Cannabinoid receptor Colorectal cancer colorectal cancer lcsh:RC254-282 Article Metastasis Malignant transformation 03 medical and health sciences 0302 clinical medicine Medicine metastasis endocannabinoid system Receptor business.industry Cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Primary tumor 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Signal transduction business cannabinoid type 1 (CB1) receptor |
| Zdroj: | Cancers Volume 11 Issue 5 Cancers, Vol 11, Iss 5, p 708 (2019) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11050708 |
| Popis: | Changes in the regulation of endocannabinoid production, together with an altered expression of their receptors are hallmarks of cancer, including colorectal cancer (CRC). Although several studies have been conducted to understand the biological role of the CB1 receptor in cancer, little is known about its involvement in the metastatic process of CRC. The aim of this study was to investigate the possible link between CB1 receptor expression and the presence of metastasis in patients with CRC, investigating the main signaling pathways elicited downstream of CB1 receptor in colon cancer. Fifty-nine consecutive patients, with histologically proven colorectal cancer, were enrolled in the study, of which 30 patients with synchronous metastasis, at first diagnosis and 29 without metastasis. A low expression of CB1 receptor were detected in primary tumor tissue of CRC patients with metastasis and consequently, we observed an alteration of CB1 receptor downstream signaling. These signaling routes were also altered in intestinal normal mucosa, suggesting that, normal mucosa surrounding the tumor provides a realistic picture of the molecules involved in tissue malignant transformation. These observations contribute to the idea that drugs able to induce CB1 receptor expression can be helpful in order to set new anticancer therapeutic strategies. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
| Databáze: | OpenAIRE |
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