Kinetic analysis of red pigment and citrinin production by Monascus ruber as a function of organic acid accumulation
| Autor: | Jean-Louis Uribelarrea, Gérard Goma, Philippe Blanc, Pascal Loubière, Hassan Hajjaj, Evelyne Groussac |
|---|---|
| Přispěvatelé: | Unité mixte de recherche biotechnologies bioprocédés, Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
0106 biological sciences
Bioengineering Secondary metabolite Biology 01 natural sciences Applied Microbiology and Biotechnology Biochemistry 03 medical and health sciences chemistry.chemical_compound Pigment 010608 biotechnology medicine Mycotoxin ComputingMilieux_MISCELLANEOUS 030304 developmental biology chemistry.chemical_classification 0303 health sciences Primary metabolite Monascus biology.organism_classification Citrinin [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology chemistry visual_art visual_art.visual_art_medium Malic acid Biotechnology medicine.drug Organic acid |
| Zdroj: | Enzyme and Microbial Technology Enzyme and Microbial Technology, Elsevier, 2000, 27, pp.619-625 Enzyme and Microbial Technology, 2000, 27, pp.619-625 |
| ISSN: | 0141-0229 |
| Popis: | In submerged cultures performed in synthetic medium containing glucose and glutamate, the filamentous fungus Monascus ruber produced a red pigment and a mycotoxin, citrinin. In oxygen-limiting conditions, the production of these two metabolites was growth-associated, as was the production of primary metabolites. In oxygen-excess conditions, the profile of citrinin production was typical of a secondary metabolite, since it was produced mostly during the stationary phase. In contrast, the production of the pigment decreased rapidly throughout the culture, showing a profile characteristic of an inhibitory mechanism. The organic acids produced during the culture, L-malate and succinate, were shown to be slightly inhibitory against pigment production, while citrinin production was unaffected. However, this inhibition could not account for the observed profile of pigment production in batch cultures. Other dicarboxylic acids such as fumarate or tartrate showed a similar effect to that provoked by malate and succinate as regards pigment production. It was concluded that the decrease in red pigment production during the culture was due to the inhibitory effect of an unknown product whose accumulation was favored in aerobic conditions. |
| Databáze: | OpenAIRE |
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