Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq.) Sargent hexane leaf extract
| Autor: | James Oluwagbamigbe Fajemiroye, P.M. Ferreira, Elson Alves Costa, Paulo César Ghedini, Fábio Borges de Sousa, José Luís Rodrigues Martins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cannabaceae
lcsh:RS1-441 Pharmacology Rana Lesion lcsh:Pharmacy and materia medica chemistry.chemical_compound Pharmacy and materia medica lcsh:Botany Celtis iguanaea antiulcerogenic activity medicine Secretion biology Botany extrato hexânico Cerrado atividade antisecretória biology.organism_classification lcsh:QK1-989 Hexane RS1-441 atividade anti-ulcerogênica Complementary and alternative medicine chemistry Biochemistry QK1-989 hexane extract Gastric acid medicine.symptom Histamine antisecretory activity |
| Zdroj: | Revista Brasileira de Plantas Medicinais, Vol 16, Iss 2, Pp 250-255 (2014) Revista Brasileira de Plantas Medicinais v.16 n.2 2014 Revista brasileira de plantas medicinais Universidade Estadual Paulista (UNESP) instacron:SBPM |
| Popis: | The Celtis iguanaea (Jacq.) Sargent (Cannabaceae) is one of the native species of the Cerrado region of Brazil widely used in folk medicine to treat dyspepsia. The objective of the present study was to evaluate the gastroprotective effect of the Celtis iguanaea (Jacq.) Sargent (HE) hexane leaf extract in the lesion and gastric secretion models.Antiulcerogenic activity of the Celtis iguanaea (HE) hexane leaf extract was observed with the experimental models, such as indomethacin and pyloric ligation-induced gastric ulcers. In order to evaluate the antisecretory activity of this extract, isolated Rana catesbeiana mucosa and pyloric ligation in mice were used. The HE treatment reduced the lesion index of indomethacin and pyloric ligation-induced ulcer. This extract also reduced the gastric acid secretion and total acidity (increasing the gastric pH) in mice. The secretion of H+ was reduced in the basal values (15.58 ± 1.99 µEq H+/g/15 min) when isolated Rana catesbeiana mucosa was incubated with HE. Intraduodenal administration of HE reduced the gastric secretion produced by bethanecol or histamine. The antiulcerogenic and antisecretory efficacy of HE in this study suggest anticholinergic and antihistaminergic mechanism or interruption of intracellular events that are linked to acid secretion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|