Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes

Autor: Laurent, Schmied, Grzegorz, Terszowski, Asensio, Gonzalez, Karin, Schmitter, Hans H, Hirsch, Christian, Garzoni, Christian, van Delden, Katia, Boggian, Nicolas J, Mueller, Christoph, Berger, Jean, Villard, Oriol, Manuel, Pascal, Meylan, Christoph, Hess, Martin, Stern, Patrick, Yerly
Přispěvatelé: University of Zurich, Stern, Martin
Rok vydání: 2015
Předmět:
Graft Rejection
Male
Herpesvirus 3
Human
2747 Transplantation
viruses
Killer-cell immunoglobulin-like receptor
Chickenpox/prevention & control/virology
medicine.disease_cause
Virus Replication
10234 Clinic for Infectious Diseases
0302 clinical medicine
Chickenpox
Receptors
KIR
immune system diseases
Genotype
Child
Kidney transplantation
ddc:616
0303 health sciences
virus diseases
hemic and immune systems
Middle Aged
3. Good health
Child
Preschool
embryonic structures
10209 Clinic for Cardiology
Female
Virus Replication/genetics
Adult
medicine.medical_specialty
Adolescent
Receptors
KIR/genetics
chemical and pharmacologic phenomena
610 Medicine & health
Graft Rejection/immunology/prevention & control
Virus
03 medical and health sciences
Young Adult
otorhinolaryngologic diseases
medicine
Humans
030304 developmental biology
Aged
Retrospective Studies
Transplantation
business.industry
Varicella zoster virus
Infant
Newborn
Infant
medicine.disease
Virology
Kidney Transplantation
Herpesvirus 3
Human/genetics
Transplant Recipients
Surgery
Viral replication
Haplotypes
Infectious disease (medical specialty)
10036 Medical Clinic
business
Polyomavirus Infections
030215 immunology
Follow-Up Studies
Zdroj: TRANSPLANTATION
Transplantation, Vol. 99, No 12 (2015) pp. 2651-5
ISSN: 0041-1337
DOI: 10.1097/TP.0000000000000778
Popis: BACKGROUND: Natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (KIR). Previous studies have documented associations of KIR genotype with the risk of cytomegalovirus (CMV) replication after solid organ transplantation. METHODS: In this study of 649 solid organ transplant recipients, followed prospectively for infectious disease events within the Swiss Transplant Cohort Study, we were interested to see if KIR genotype associated with virus infections other than CMV. RESULT: We found that KIR B haplotypes (which have previously been linked to protection from CMV replication) were associated with protection from varicella zoster virus infection (hazard ratio, 0.43; 95% confidence interval, 0.21-0.91; P = 0.03). No significant associations were detected regarding the risk of herpes simplex, Epstein-Barr virus or BK polyomavirus infections. CONCLUSIONS: In conclusion, these data provide evidence that the relative protection of KIR haplotype B from viral replication after solid organ transplantation may extend beyond CMV to other herpes viruses, such as varicella zoster virus and possibly Epstein-Barr virus.
Databáze: OpenAIRE
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