Synthesis and SAR of novel histamine H3 receptor antagonists

Autor:	Samuel W. Oldham, M. Joelle Dill, Brian Morgan Watson, Craig W. Lindsley, Don Richard Finley, Dana Sindelar, Lisa Selsam Beavers, Cynthia Darshini Jesudason, Philip Arthur Hipskind, Robert Alan Gadski, Ajay Singh, Christopher Stephen Siedem, Jeffrey W Cramer, R. Todd Pickard, F. Craig Stevens
Rok vydání:	2006
Předmět:	Stereochemistry Clinical Biochemistry Substituent Drug Evaluation Preclinical Pharmaceutical Science Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Tetrahydroisoquinolines Drug Discovery Structure–activity relationship Animals Humans Receptors Histamine H3 Receptor Molecular Biology Molecular Structure Tetrahydroisoquinoline Organic Chemistry Biological activity Azepines Rats chemistry Molecular Medicine Histamine H3 receptor Selectivity
Zdroj:	Bioorganicmedicinal chemistry letters. 16(13)
ISSN:	0960-894X
Popis:	The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac411e9c4aa2b7b111ec41de2547f44 https://pubmed.ncbi.nlm.nih.gov/16677814 Zobrazit plný text záznamu Full Text from ScienceDirect