Pathologic and Clinical Characteristics of Elderly Patients With Breast Cancer: A Retrospective Analysis of a Multicenter Study (Anatolian Society of Medical Oncology)
| Autor: | Suleyman Alici, Hüseyin Engin, Selcuk Cemil Ozturk, Hakan Harputoglu, Cem Boruban, Tulay Tamozlu, Ozan Balakan, Caglayan Geredeli, Sebnem Yaman, Gamze Goksel, Suleyman Buyukberber, Özlem Sönmez, Mevlude Inanc, Gamze Gokoz Dogu, Ali Inal, Havva Yesil Cinkir, Mehmet Bilici, Olcun Umit Unal, Abdurrahman Isikdogan, Umut Demirci, Tulay Akman, Dilsen Colak |
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| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male retrospective study very elderly survival analysis Breast cancer Retrospective analysis Neoplasm Metastasis multimodality cancer therapy Aged 80 and over lymph node metastasis Treatment choices Age Factors clinical trial Prognosis Combined Modality Therapy medicine.anatomical_structure female Lymphatic Metastasis Breast and Endocrine Surgery Female medicine.medical_specialty MEDLINE Breast Neoplasms Adenocarcinoma Breast Neoplasms Male Internal medicine medicine metastasis Humans Pathologic characteristics human Survival analysis Aged Retrospective Studies Clinical characteristics business.industry Retrospective cohort study medicine.disease Survival Analysis mortality Elderly patients Axilla axilla multicenter study Multicenter study age Surgery pathology business |
| Popis: | WOS: 000330382700002 PubMed: 24444261 There is very little information about breast cancer characteristics, treatment choices, and survival among elderly patients. The purpose of this multicenter retrospective study was to examine the clinical, pathologic, and biologic characteristics of 620 breast cancer patients age 70 years or older. Between June 1991 and May 2012, 620 patients with breast cancer, recruited from 16 institutions, were enrolled in the retrospective study. Patients had smaller tumors at diagnosis; only 15% of patients had tumors larger than 5 cm. The number of patients who had no axillary lymph node involvement was 203 (32.7%). Ninety-three patients (15.0%) had metastatic disease at diagnosis. Patients were characterized by a higher fraction of pure lobular carcinomas (75.3%). The tumors of the elderly patients were also more frequently estrogen receptor (ER) positive (75.2%) and progesterone receptor (PR) positive (67.3%). The local and systemic therapies for breast cancer differed according to age. An association between age and overall survival has not been demonstrated in elderly patients with breast cancer. In conclusion, the biologic behavior of older patients with breast cancer differs from younger patients, and older patients receive different treatments. |
| Databáze: | OpenAIRE |
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