Early exercise regimen improves insulin sensitivity in the intrauterine growth-restricted adult female rat offspring

Autor: Manikkavasagar Thamotharan, Duncan C. MacLaren, Sherin U. Devaskar, Paul W. N. Lee, Gerald Pan, Shilpa A. Oak, Meena Garg
Rok vydání: 2009
Předmět:
Blood Glucose
congenital
hereditary
and neonatal diseases and abnormalities

medicine.medical_specialty
Time Factors
Physiology
Offspring
Endocrinology
Diabetes and Metabolism

medicine.medical_treatment
Biology
Rats
Sprague-Dawley

Insulin resistance
Pregnancy
Physical Conditioning
Animal

Physiology (medical)
Internal medicine
medicine
Animals
Insulin
Body Weights and Measures
reproductive and urinary physiology
computer.programming_language
Glucose tolerance test
Fetal Growth Retardation
medicine.diagnostic_test
sed
Skeletal muscle
Articles
Glucose Tolerance Test
medicine.disease
female genital diseases and pregnancy complications
Rats
Glucose
Endocrinology
medicine.anatomical_structure
Animals
Newborn

Basal (medicine)
Prenatal Exposure Delayed Effects
embryonic structures
biology.protein
Female
Insulin Resistance
computer
Algorithms
GLUT4
Zdroj: American Journal of Physiology-Endocrinology and Metabolism. 296:E272-E281
ISSN: 1522-1555
0193-1849
DOI: 10.1152/ajpendo.90473.2008
Popis: We examined the effect of early exercise training (Ex) on glucose kinetics, basal, and insulin-stimulated skeletal muscle (SKM) plasma membrane (PM) GLUT4 in pre- and/or postnatal nutrient-restricted adult rat offspring compared with sedentary (Sed) state. Pregestational control female (Ex CON vs. Sed CON) and offspring exposed to prenatal (Ex IUGR vs. Sed IUGR), postnatal (Ex PNGR vs. Sed PNGR), or pre- and postnatal (Ex IUGR + PNGR vs. Sed IUGR + PNGR) nutrient restriction were studied. The combined effect of exercise and pre/postnatal nutrition in the Ex IUGR demonstrated positive effects on basal and glucose-stimulated plasma insulin response (GSIR) with suppression of endogenous hepatic glucose production (HGP) compared with sedentary state. Ex PNGR was hyperglycemic after glucose challenge with no change in glucose-stimulated insulin production or HGP compared with sedentary state. Ex IUGR + PNGR remained glucose tolerant with unchanged glucose-stimulated insulin production but increased endogenous HGP compared with sedentary state. Basal SKM PM-associated GLUT4 was unchanged by exercise in all four groups. Whereas Ex PNGR and Ex IUGR + PNGR insulin responsiveness was similar to that of Ex CON, Ex IUGR remained nonresponsive to insulin. Early introduction of regular Ex in the pregestational female offspring had a positive effect on hepatic adaptation to GSIR and HGP in IUGR and IUGR + PNGR, with no effect in PNGR. Change in insulin responsiveness of SKM GLUT4 translocation was observed in exercised IUGR + PNGR and PNGR but not in exercised IUGR.
Databáze: OpenAIRE