Breeding for high specific immune reactivity affects sensitivity to the environment
| Autor: | Henk K. Parmentier, Ger de Vries Reilingh, Mike G.B. Nieuwland, Laura P. M. Verhofstad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
responsiveness Oviposition chemical and pharmacologic phenomena Breeding Body weight Weight Gain Antibodies bacterial-endotoxin Immune system medicine Animals Humans red-blood-cells dendritic cells Adaptatiefysiologie Poultry Diseases Serum Albumin biology poultry Interleukin General Medicine Immune modulation Human serum albumin intratracheal lipopolysaccharide Housing Animal Immunity Innate Vaccination secondary antibody-responses molecular-patterns Air Pollution Indoor Immunology biology.protein WIAS Immune reactivity Adaptation Physiology chickens Animal Science and Zoology Keyhole limpet hemocyanin interleukin-1 medicine.drug |
| Zdroj: | Poultry Science, 91(12), 3044-3051 Poultry Science 91 (2012) 12 |
| ISSN: | 0032-5791 |
| Popis: | Lipopolysaccharides (LPS) are present in high levels in the air of chicken houses and likely have immune-modulating effects. In this study, layers from the 30th generation of a divergent selection experiment for humoral immune reactivity to subcutaneously administered sheep red blood cells were concurrently intratracheally challenged with human serum albumin (HuSA) and LPS at 7 and 12 wk of age following a crossing over design. Chickens selected for high humoral immune reactivity (H line) showed higher specific antibody responses to intratracheally administered HuSA and a higher level of natural antibody binding keyhole limpet hemocyanin compared with chickens genetically selected for low humoral immune reactivity (L line), and were also more sensitive to immune modulation by LPS at 7 wk of age. Body weight gain was negatively affected by LPS at 7 wk of age in the L line, but after 12 wk of age in the H line. Egg production was lower and delayed in the H line. We conclude that these chicken selection lines differ in sensitivity to the environment (LPS), and consequently may therefore also react differently to infection, vaccinations, and other immune responses. In addition, selection for immune responsiveness affected growth and egg lay. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|