18F-labeled resin microspheres as surrogates for 90Y resin microspheres used in the treatment of hepatic tumors: a radiolabeling and PET validation study
| Autor: | J C McDermott, T F Warner, Christine Jaskowiak, Bruce R. Thomadsen, Robert J. Nickles, Miguel A. Avila-Rodriguez, Reed Selwyn, Joseph A. Hampel, Alexander K. Converse |
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| Rok vydání: | 2007 |
| Předmět: |
Validation study
Carcinoma Hepatocellular Patient response Resin microsphere Sensitivity and Specificity Microsphere Rats Sprague-Dawley In vivo Fluorodeoxyglucose F18 medicine Animals Humans Radiology Nuclear Medicine and imaging Yttrium Radioisotopes Radiological and Ultrasound Technology medicine.diagnostic_test Chemistry business.industry Standard treatment Liver Neoplasms Reproducibility of Results Radiotherapy Dosage Pet imaging Embolization Therapeutic Microspheres Rats Positron emission tomography Positron-Emission Tomography Rabbits Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Physics in medicine and biology. 52(24) |
| ISSN: | 0031-9155 |
| Popis: | (90)Y-labeled resin microspheres (SIR-Spheres) are currently used to treat patients with primary and metastatic solid liver tumors. This treatment is typically palliative since patients have exhausted all other standard treatment options. Improving the quality of life and extending patient survival are typical benchmarks for tracking patient response. However, the current method for predicting microsphere biodistributions with (99m)Tc-labeled macroaggregated albumin (MAA) does not correlate well with patient response. This work presents the development of a new (18)F-labeled resin microsphere to serve as a surrogate for the treatment microsphere and to employ the superior resolution and sensitivity of positron emission tomography (PET). The (18)F microsphere biodistributions were determined in a rabbit using PET imaging and histological review. The PET-based uptake ratio was shown to agree with the histological findings to better than 3%. In addition, the radiolabeling process was shown to be rapid, efficient and relatively stable in vivo. |
| Databáze: | OpenAIRE |
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