Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders
| Autor: | Monica Aas, Trine Vik Lagerberg, Sébastien Gard, Frank Bellivier, Bruno Etain, Sofie R. Aminoff, C. Henry, Marion Leboyer, Mohamed Lajnef, Thomas Bjella, Ole A. Andreassen, Jean-Pierre Kahn, Ingrid Melle |
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| Přispěvatelé: | University of Oslo (UiO), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Fondation FondaMental [Créteil], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Etain, Bruno |
| Rok vydání: | 2016 |
| Předmět: |
Male
Bipolar Disorder clinical features MESH: Adult Survivors of Child Adverse Events childhood maltreatment [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Suicide Attempted MESH: Comorbidity Comorbidity 0302 clinical medicine MESH: Bipolar Disorder Age of Onset Applied Psychology MESH: Aged MESH: Middle Aged Norway Lability Middle Aged Anxiety Disorders Psychiatry and Mental health Adult Survivors of Child Adverse Events MESH: Young Adult MESH: Suicide Attempted Anxiety Female Diagnostic Interview for Genetic Studies France medicine.symptom Psychology Clinical psychology Psychopathology Adult Mediation (statistics) medicine.medical_specialty Adolescent MESH: Age of Onset MESH: Psychotic Disorders Young Adult MESH: Norway 03 medical and health sciences Bipolar disorders medicine Humans Psychiatry Association (psychology) Aged MESH: Adolescent MESH: Humans CTQ tree MESH: Adult MESH: Male 030227 psychiatry MESH: France Mood Psychotic Disorders [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health MESH: Anxiety Disorders MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine Psychological Medicine, Cambridge University Press (CUP), 2017, 47 (5), pp.902-912. ⟨10.1017/S0033291716003081⟩ |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291716003081 |
| Popis: | BackgroundMany studies have shown associations between a history of childhood trauma and more severe or complex clinical features of bipolar disorders (BD), including suicide attempts and earlier illness onset. However, the psychopathological mechanisms underlying these associations are still unknown. Here, we investigated whether affective lability mediates the relationship between childhood trauma and the severe clinical features of BD.MethodA total of 342 participants with BD were recruited from France and Norway. Diagnosis and clinical characteristics were assessed using the Diagnostic Interview for Genetic Studies (DIGS) or the Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I). Affective lability was measured using the short form of the Affective Lability Scale (ALS-SF). A history of childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ). Mediation analyses were performed using the SPSSprocessmacro.ResultsUsing the mediation model and covariation for the lifetime number of major mood episodes, affective lability was found to statistically mediate the relationship between childhood trauma experiences and several clinical variables, including suicide attempts, mixed episodes and anxiety disorders. No significant mediation effects were found for rapid cycling or age at onset.ConclusionsOur data suggest that affective lability may represent a psychological dimension that mediates the association between childhood traumatic experiences and the risk of a more severe or complex clinical expression of BD. |
| Databáze: | OpenAIRE |
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