Schwartz’s Reagent-Mediated Regiospecific Synthesis of 2,3-Disubstituted Indoles from Isatins
| Autor: | Artur Ulikowski, Bartłomiej Furman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Isatin
Indoles Molecular Structure 010405 organic chemistry Organic Chemistry Stereoisomerism 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Nucleophile Reagent Yield (chemistry) Schwartz's reagent Organometallic Compounds Organic chemistry Physical and Theoretical Chemistry Group 2 organometallic chemistry |
| Zdroj: | Organic Letters. 18:149-151 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.5b03449 |
| Popis: | An expeditious, functional group-tolerant synthesis of indoles from isatins is described. Isatins are treated with Grignard reagents to yield oxindoles. These, in turn, are reduced with Schwartz's reagent and subjected to nucleophile addition and dehydration to yield 2,3-disubstituted indoles regiospecifically. This represents a divergent approach to the synthesis of these medicinally and synthetically important compounds. |
| Databáze: | OpenAIRE |
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