Limited but evident protective effects of MK-801 and pentobarbital on neuronal damage following forebrain ischemia in the gerbil under normothermic conditions
| Autor: | Hiroyuki Kato, Kyuya Kogure, Kenshi Murase |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Pentobarbital Carotid Artery Common Ischemia Hippocampus Hippocampal formation Pharmacology Gerbil Body Temperature Adenosine Triphosphate medicine Animals cardiovascular diseases Neurons Cell Death business.industry General Neuroscience Glutamate receptor medicine.disease Dizocilpine Ischemic Attack Transient Anesthesia NMDA receptor Dizocilpine Maleate Gerbillinae business medicine.drug |
| Zdroj: | Neuroscience Letters. 149:229-232 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(93)90778-j |
| Popis: | The purpose of this study was to examine the protective effects of an N- methyl- d -aspartate receptor antagonist, MK-801, and pentobarbital against neuronal damage in a global ischemia model under controlled body temperature. Gerbils were subjected to 3 and 5 min of bilateral common carotid artery occlusion. MK-801 (1 and 5 mg/kg, i.p.), administered 30 min before ischemia, significantly attenuated the degeneration of hippocampal CA1 pyramidal cells after 3 min of ischemia in a dose dependent manner, but had no such effects after 5 min of ischemia. Pentobarbital (40 mg/kg, i.p.) also protected against CA1 damage after 3 min of ischemia but not after 5 min of ischemia. Thus, we confirmed the protective effects of these agents under normothermic conditions, although these effects were limited to shorter periods of ischemia. |
| Databáze: | OpenAIRE |
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