Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol
| Autor: | Giordana Zanna, Mar Bardagí, Ivan Ravera, Xavier Roura, Marta Torres, Lluís Ferrer |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Allopurinol medicine.medical_treatment Meglumine antimoniate Antiprotozoal Agents Arthritis Severity of Illness Index Gastroenterology Dogs Meglumine Pharmacotherapy Internal medicine Severity of illness Organometallic Compounds medicine Animals Dog Diseases Leishmaniasis Hydronephrosis Meglumine Antimoniate General Veterinary business.industry medicine.disease Nephrectomy Surgery Treatment Outcome Drug Therapy Combination Female Animal Science and Zoology business Uveitis Follow-Up Studies medicine.drug |
| Zdroj: | The Veterinary Journal. 188:346-351 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2010.05.025 |
| Popis: | Twenty-three dogs with a diagnosis of leishmaniosis (clinical stage II) were treated with meglumine antimoniate and allopurinol and were followed up for 2-9 years. The treatment showed efficacy and the clinical condition of the dogs improved markedly in the first 3 months of treatment. Anti-Leishmania antibody titres declined slowly although most dogs remained seropositive 1 year after beginning treatment. Inter-individual variability in the evolution of the titres was very high. The dogs presented with three types of complications during the follow-up period. (1) Three dogs experienced relapses characterized by clinical signs, high anti-Leishmania titres and high parasitaemia. (2) Eight dogs presented immune-mediated lesions, such as uveitis, arthritis and cutaneous vasculitis; in all of these cases, the dogs had high titres of anti-Leishmania antibodies at diagnosis and during follow-up. (3) Three dogs presented xanthine urolithiasis most likely due to the allopurinol treatment. In one case the xanthine uroliths led to hydronephrosis and nephrectomy. The study demonstrated a long survival for dogs with leishmaniosis treated with the combination of meglumine antimoniate and allopurinol. Clinicians should pay special attention to the appearance of immune-mediated lesions, especially in dogs with sustained high antibody titres, and to urolithiasis. |
| Databáze: | OpenAIRE |
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