The 28-Day Mortality Outcome of the Complete Hour-1 Sepsis Bundle in the Emergency Department
| Autor: | Pitsucha Sanguanwit, Thidathit Prachanukool, Karn Suttapanit, Fuangsiri Thodamrong |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Surviving Sepsis Campaign emergency department Sepsis bundle Critical Care and Intensive Care Medicine Clinical Science Aspects Cohort Studies Sepsis Sequential Organ Failure Assessment qSOFA antibiotic Internal medicine medicine SOFA Humans Prospective Studies Prospective cohort study Aged Aged 80 and over ATB Septic shock business.industry quick Sequential Organ Failure Assessment 28-Day mortality Emergency Physician Emergency department Middle Aged medicine.disease ED Shock Septic Confidence interval Clinical trial EP hour-1 sepsis bundle Emergency Medicine septic shock Female Emergency Service Hospital business Patient Care Bundles |
| Zdroj: | Shock (Augusta, Ga.) |
| ISSN: | 1540-0514 1073-2322 |
| Popis: | Introduction: The Surviving Sepsis Campaign published the Hour-1 Sepsis Bundle in 2018. The first-hour management of patients with sepsis in the emergency department (ED) is important, as suggested in the Hour-1 Sepsis Bundle. The objectives of the present study were to evaluate 28-day mortality and delayed septic shock with use of a complete and incomplete Hour-1 Sepsis Bundle in the ED. Methods: This prospective cohort study included adult patients with sepsis from March to July 2019. We followed the sepsis protocol used in the ED of a tertiary care hospital. Results: We enrolled 593 patients, with 55.9% in the complete Hour-1 Sepsis Bundle group. The 28-day mortality was 3.9% overall and no significant difference between the complete and incomplete Hour-1 Sepsis Bundle groups (3.6% vs. 4.2%, P = 0.707). Complete Hour-1 Sepsis Bundle treatment was not associated with 28-day mortality (adjusted OR = 2.04, 95% confidence interval [CI] = 0.72–5.74, P = 0.176) or delayed septic shock (adjusted OR = 0.74, 95% CI = 0.30–1.78, P = 0.499). Completion of each bundle did not affect outcomes of 28-day mortality and delayed septic shock. Conclusions: The complete Hour-1 Sepsis Bundle treatment in the ED was not significantly associated with 28-day mortality and delayed septic shock. Trial registration: The trial was registered in the Thai Clinical Trial Registry, TCTR 20200526013. |
| Databáze: | OpenAIRE |
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