Enantioselective α-Arylation of O-Carbamates via Sparteine-Mediated Lithiation and Negishi Cross-Coupling

Autor:	Titouan Royal, Yann Baumgartner, Olivier Baudoin
Rok vydání:	2016
Předmět:	010405 organic chemistry Negishi coupling Stereochemistry Chemistry Organic Chemistry Enantioselective synthesis Sparteine 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences medicine Physical and Theoretical Chemistry medicine.drug
Zdroj:	Organic Letters. 19:166-169
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.6b03472
Popis:	A general and highly enantioselective arylation of carbamates derived from primary alcohols was developed by combining Hoppe's sparteine-mediated asymmetric lithiation with Negishi cross-coupling. Coupled with Aggarwal's lithiation-borylation sequence, the current method provides a short and divergent access to a variety of enantioenriched secondary and tertiary benzylic alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab1f629797999c3a7c51430b1d43019 https://doi.org/10.1021/acs.orglett.6b03472 Zobrazit plný text záznamu