Birth Weight Standard Deviation Score is a Significant Determinant of Serum Urotensin-II Levels at Term-Equivalent Age in Preterm Infants
| Autor: | Takanari Fujii, Katsumi Mizuno, Akio Ebata, Yuya Nakano, Gakuto Ujiie, Yoko Ishii, Takeshi Shimizu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
Adult Male medicine.medical_specialty Birth weight Urotensins 030209 endocrinology & metabolism Gestational Age 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Medicine Birth Weight Humans Vasoconstrictor Agents business.industry Obstetrics Term equivalent age Infant Newborn Obstetrics and Gynecology Gestational age Infant medicine.disease Atherosclerosis Low birth weight chemistry Pediatrics Perinatology and Child Health Hypertension Infant Small for Gestational Age Population study Small for gestational age Female medicine.symptom business Urotensin-II Infant Premature |
| Zdroj: | American journal of perinatology. 39(9) |
| ISSN: | 1098-8785 |
| Popis: | Objective Urotensin II (U-II) is a potent vasoconstrictor peptide, and increased U-II levels are associated with atherosclerosis and hypertension in adults. Low birth weight (LBW) infants have higher risks of such diseases in the future. A small number of nephrons is one of possible mechanism underlying these risks in LBW infants, while vascular elasticity and cardiac function might be another important factor. The objective of this study is to evaluate U-II levels in preterm LBW infants at an early stage of life and determine perinatal factors associated with U-II levels. Study Design The study population consisted of 57 preterm LBW infants (26 males and 31 females), including 49 appropriate for gestational age (AGA) and 8 small for gestational age (SGA) infants, born at a gestational age of ≤34 weeks with a mean birth weight of 1,589 g. Serum U-II levels were measured at term-equivalent age to evaluate perinatal factors related to serum U-II levels. Results Preterm SGA infants had significantly higher serum U-II levels than preterm AGA infants at term-equivalent age (p = 0.019). Serum U-II levels in preterm LBW infants at term-equivalent age were inversely correlated with birth weight standard deviation (SD) score in a simple regression analysis (r = − 0.395, p = 0,002) and the correlation was maintained in the multiple regression analysis. Conclusion Our results indicate that birth weight SD score might be associated with serum U-II levels in preterm LBW infants at term-equivalent age. Further studies are required to determine whether U-II levels at an early stage of life might influence the risk of atherosclerosis and hypertension. Key Points |
| Databáze: | OpenAIRE |
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