Nuclear compartments and gene regulation

Autor:	Moira M. Cockell, Susan M. Gasser
Rok vydání:	1999
Předmět:	Cell Nucleus Regulation of gene expression Genetics Heterochromatin Telomere Biology Cell biology medicine.anatomical_structure Gene Expression Regulation Gene expression medicine Fluorescence microscope Animals Compartment (development) Gene silencing Gene Nucleus Developmental Biology
Zdroj:	Current Opinion in Genetics & Development. 9:199-205
ISSN:	0959-437X
DOI:	10.1016/s0959-437x(99)80030-6
Popis:	Improvements in fluorescence microscopy have allowed us to explore the three-dimensional organization of the nucleus in ways that were impossible ten years ago, revealing subdomains or compartments within the nucleus defined by their enrichments of subsets of factors. Correlations have been drawn between the silencing of a gene and its proximity to a heterochromatic compartment or to the nuclear periphery. The application of genetics and high-resolution microscopy helps examine the creation, maintenance and impact of these compartments on gene expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab1ba446a87c13640b9cfec4c4539bd https://doi.org/10.1016/s0959-437x(99)80030-6 Zobrazit plný text záznamu Full Text from ScienceDirect