Influenza B viral load analysis in patients with acute respiratory infection from a tertiary hospital in Brazil
Autor: | Vitória Rodrigues Guimarães Alves, Luciano Kleber de Souza Luna, Nancy Bellei, Jessica Santiago Cruz, Ana Helena Perosa |
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Rok vydání: | 2019 |
Předmět: |
Adult
Adolescent Victoria Short Communication Short Communications Antibodies Viral Severity of Illness Index Tertiary Care Centers Young Adult 03 medical and health sciences 0302 clinical medicine Immune system Virology Influenza Human Genotype Humans Medicine In patient 030212 general & internal medicine Child Respiratory Tract Infections Aged Immune status business.industry Infant Respiratory infection Middle Aged Viral Load Vaccination Influenza B virus Yamagata Infectious Diseases Immunization Influenza Vaccines Child Preschool Female 030211 gastroenterology & hepatology business Viral load Brazil |
Zdroj: | Journal of Medical Virology |
ISSN: | 1096-9071 0146-6615 |
Popis: | Currently, 2 genotypes of Influenza B viruses (IFB) are cocirculating in humans: Victoria (VIC) and Yamagata (YAM). Infection and viral load (VL) were analyzed in 105 genotyped IFB (59 VIC and 46 YAM) out of 3452 respiratory samples from immunodepressed (ID), immunocompetent (IC) including outpatients (OP) and hospitalized patients (HP) attended during 2001‐2013 at São Paulo Hospital. VL (Log10 RNA copies/mL) calculation was possible in 78 samples (47 VIC, 31 YAM). The age group of 12 to 18 years presented the highest detection (14.13%). Rates of infection among groups were of 3.67% (IC), 1.68% (ID), 3.50% (OP), 0.6% (HP), and VLs varied from 2.8 to 10.13 with no difference regarding age, immune status, and disease severity. From 10 OP vaccinated against influenza, 8 (7 children, 1 ID) received a matching strain shot (VIC), and 2 a monovalent influenza A H1N1pdm09. Those patients presented a VL of 6.31 ± 1.62 (mean ± SD). IFB infection rates follow an age pattern, but VL seems not to be related to frequency or clinical outcome. IFB patients with previous immunization could point to some protection for VIC infections since there was no HP. Other immunological aspects, such as lineage infection immune priming, previous infections, and vaccinations, should be further investigated. Research Highlights The age group of 12–18 years old presented the highest IFB detection.IFB YAM infections occurred more frequently among those with |
Databáze: | OpenAIRE |
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