The effects of a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and MET-enkephalin in patients with adrenocortical disease
| Autor: | Ashley B. Grossman, Lesley H. Rees, G. M. Besser, R. C. Gaillard, Roger Smith |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male beta-Lipotropin Met-enkephalin endocrine system medicine.medical_specialty Enkephalin Methionine Endocrinology Diabetes and Metabolism (+)-Naloxone Disease Pituitary Irradiation Inhibitory postsynaptic potential chemistry.chemical_compound Endocrinology Addison Disease Adrenocorticotropic Hormone Opiate receptors Internal medicine D-Ala(2) MePhe(4) Met(0)-ol-enkephalin Humans Medicine In patient Cushing Syndrome Naloxone business.industry beta-Endorphin Adrenalectomy Enkephalins Middle Aged Hormones chemistry Female Bilateral adrenalectomy Endorphins business hormones hormone substitutes and hormone antagonists |
| DOI: | 10.1111/j.1365-2265.1981.tb00636.x |
| Popis: | Thirteen patients with either Addison's disease, or Cushing's disease treated by bilateral adrenalectomy, were infused with the long-acting met-enkephalin analogue DAMME. In patients with Addison's disease significant and pronounced falls in ACTH and N- and C-terminal beta-LPH were seen; chromatography suggested that beta-endorphin fell concomitantly. Three out of four patients with Cushing's disease who had not received pituitary irradiation, also showed a decrease in plasma ACTH and N- and C-terminal beta-LPH; however, no change was seen in any of the irradiated patients. The changes were naloxone reversible. The levels of plasma met-enkephalin were normal and did not change after DAMME in any group of patients. These results are interpreted as suggesting that there are inhibitory opiate receptors controlling the release of ACTH, beta-LPH, and beta-endorphin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|