De Novo Focal and Segmental Glomerulosclerosis After COVID-19 in a Patient With a Transplanted Kidney From a Donor With a High-risk APOL1 Variant
| Autor: | Aude Mausoleo, Marie Matignon, Julie Oniszczuk, Stephanie Malard-Castagnet, Anna Boueilh, Thomas Stehlé, David Buob, Marie Christine Verpont, Dil Sahali, Philippe Grimbert, Anissa Moktefi, Vincent Audard, Slim Fourati, Nicolas Pallet, Khalil El Karoui |
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| Přispěvatelé: | Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - PGD/'Pathophysiology of Glomerular Diseases' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), service Anatomie et Cytologie Pathologique, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Etablissement Français du Sang [Nantes], Department of Pathology [Cleveland, OH, USA] (School of Medicine), Case Western Reserve University [Cleveland], Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor - Service de néphrologie et transplantation, Service de Néphrologie-Transplantation [CHU Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), IMRB - 'Transfusion et Maladies du Globule Rouge' [Créteil] (U955 Inserm - UPEC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Apolipoprotein L1 [SDV]Life Sciences [q-bio] Context (language use) 030230 surgery Kidney urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Genotype medicine Humans Genotyping ComputingMilieux_MISCELLANEOUS Transplantation biology medicine.diagnostic_test Glomerulosclerosis Focal Segmental SARS-CoV-2 business.industry Not Otherwise Specified COVID-19 Glomerulosclerosis Middle Aged medicine.disease Kidney Transplantation Tissue Donors 3. Good health biology.protein 030211 gastroenterology & hepatology Renal biopsy business Nephrotic syndrome |
| Zdroj: | Transplantation Transplantation, Lippincott, Williams & Wilkins, 2021, 105 (1), pp.206-211. ⟨10.1097/TP.0000000000003432⟩ |
| ISSN: | 0041-1337 1534-6080 |
| DOI: | 10.1097/tp.0000000000003432 |
| Popis: | There is compelling evidence that renal complications in a native kidney are a major concern in patients infected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). The spectrum of renal lesions observed on renal grafts in this context remains to be determined.We report the case of a renal transplant recipient with non-severe COVID-19, who subsequently developed nephrotic syndrome associated with acute renal injury.Renal biopsy demonstrated focal and segmental glomerulosclerosis lesions classified as not otherwise specified histological variant. Genotyping for 2 risk alleles of the apolipoprotein L1 gene demonstrated that the donor was homozygous for the G2/G2 genotype.In renal transplant patients receiving kidneys from donors with high-risk apolipoprotein L1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis. |
| Databáze: | OpenAIRE |
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