Effects of zinc supplementation on linear growth in beta-thalassemia (A new approach)
| Autor: | J. Erten, S. Gözdaşoğlu, E. Babacan, Cavdar Ao, Arcasoy A, Nejat Akar, Ş. Cin |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Percentile Adolescent medicine.medical_treatment chemistry.chemical_element Zinc Internal medicine medicine Adjuvant therapy Humans Child Growth Disorders Chemotherapy Sulfates business.industry Infant Beta thalassemia Hematology medicine.disease Body Height Zinc Sulfate Hemoglobinopathy Endocrinology chemistry Child Preschool Zinc deficiency Thalassemia Female Transfusion therapy business |
| Zdroj: | American Journal of Hematology. 24:127-136 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.2830240203 |
| Popis: | Linear growth was evaluated in 32 patients with beta-thalassemia major. At the beginning of the study of 40.6% of the patients were below the 10th percentile with biochemical evidence of zinc deficiency. Effects of zinc supplementation on growth velocity (height) were assessed in a controlled manner. Twenty-one children received oral zinc sulphate for a period of 1 to 7 years (15 early- and 6 late-supplemented cases), while the remaining 11 thalassemics were maintained only on conventional transfusion therapy. The mean height velocity of early-zinc supplemented children was significantly greater than that of normal children (P less than 0.01). An increase in height was also observed in the patients who received delayed zinc retardation. The present study demonstrated that zinc deficiency is one of the factors responsible for retarded linear growth in beta-thalassemia major. Only the patients who received zinc supplementation showed an acceleration of growth in height. Administration of zinc could, therefore, be considered as an effective adjuvant therapy in homozygous beta-thalassemia. |
| Databáze: | OpenAIRE |
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