Preparation and physical characterization of forms II and III of paracetamol

Autor:	P. Conflant, A.-M. Guyot-Hermann, J. P. Huvenne, M. Drache, P. Di Martino
Rok vydání:	1997
Předmět:	Polymorphism (materials science) Stereochemistry Chemistry Infrared Physical chemistry Recrystallization (metallurgy) Thermal analysis Powder diffraction
Zdroj:	Journal of thermal analysis. 48:447-458
ISSN:	1572-8943 0022-5215
DOI:	10.1007/bf01979491
Popis:	The polymorphic forms II and III of paracetamol were obtained by melting the marketed form I. Under the melting and cooling conditions used, it was possible to obtain forms I, II and III. The recrystallization conditions and the physical properties of forms II and III were investigated by means of various techniques: thermomicroscopy, DSC analysis, infrared microspectrometry and X-ray powder diffraction at room temperature and as a function of temperature. Form III was found to be very unstable. However, its formation seems to be an important intermediate step in the preparation of form II.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab07f8e44e341fcd5634ab6ef660ef3 https://doi.org/10.1007/bf01979491 Zobrazit plný text záznamu Full text from SpringerLink