Novel biomechanical quantification methodology for lumbar intraforaminal spinal nerve adhesion in a laminectomy and disc injury rat model
| Autor: | Vedant A. Kulkarni, Wayne H. Akeson, Mark Murphy, Florian Zauner, Jennifer B. Massie |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pain Threshold medicine.medical_specialty Cauda Equina Nerve root Spinal stenosis medicine.medical_treatment Tissue Adhesions Models Biological Rats Sprague-Dawley Spinal Stenosis Lumbar Ganglia Spinal medicine Animals Intervertebral Disc Radiculopathy Intervertebral foramen Pain Postoperative Lumbar Vertebrae business.industry General Neuroscience Laminectomy Cauda equina medicine.disease Fibrosis Low back pain Biomechanical Phenomena Rats Surgery Disease Models Animal Spinal Nerves medicine.anatomical_structure Spinal nerve Anesthesia Dura Mater medicine.symptom Spinal Nerve Roots business Low Back Pain Intervertebral Disc Displacement |
| Zdroj: | Journal of Neuroscience Methods. 166:20-23 |
| ISSN: | 0165-0270 |
| DOI: | 10.1016/j.jneumeth.2007.06.025 |
| Popis: | Spinal nerve fibrosis following injury or surgical intervention may play an important role in the pathophysiology of chronic back pain. In this current study, we demonstrate the role of biomechanical quantification of lumbar intraforaminal spinal nerve adhesion and tethering in the analysis of the post-laminectomy condition and describe a direct methodology to make this measurement. Twenty age-matched Sprague-Dawley male rats were divided into operative and non-operative (control) groups. Operative animals underwent a bilateral L5-L6 laminectomy with right-side L5-6 disc injury, a post-laminectomy pain model previously published by this lab. At eight weeks, animals were sacrificed and the strength of adhesion of the L5 intraforaminal spinal nerve to surrounding structures was quantified using a novel biomechanical methodology. Operative animals were found to have a significantly greater load to displace the intact right L5 spinal nerve through the intervertebral foramen when compared to control animals. The findings show that the post-laminectomy condition creates quantifiable fibrosis of the spinal nerve to surrounding structures and supports the conclusion that this fibrosis may play a role in the post-laminectomy pain syndrome. |
| Databáze: | OpenAIRE |
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