Impact of carbapenem administration on systemic endotoxemia in patients with severe sepsis and Gram-negative bacteremia
| Autor: | Evangelos J. Giamarellos-Bourboulis, K Rigas, G Thomopoulos, P Vernikos, N Archontoulis, Helen Giamarellou, I Pavleas, A Mega |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Carbapenem Imipenem medicine.drug_class Antibiotics Cilastatin Imipenem Drug Combination Bacteremia Gastroenterology Meropenem Microbiology Sepsis Internal medicine polycyclic compounds medicine Humans Pharmacology (medical) Antibacterial agent Aged Pharmacology Aged 80 and over Cilastatin business.industry Interleukin-6 Pneumonia Ventilator-Associated biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses medicine.disease Endotoxemia Anti-Bacterial Agents Drug Combinations Infectious Diseases C-Reactive Protein Oncology Carbapenems Female business Gram-Negative Bacterial Infections medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1120-009X |
| Popis: | In order to investigate the effect of carbapenems on systemic endotoxemia, 20 patients with severe sepsis due to ventilator-associated pneumonia and Gram-negative bacteremia were enrolled; 10 (group A) were administered 1 g t.i.d. of imipenem/cilastatin and 10 (group B) 2 g t.i.d. of meropenem. Blood was sampled at 0 time and after 1, 2, 4, 6, 12, 24, 36, 48, 60, 72, 84 and 96 hours for detection of endotoxins (LPS), interleukin-6 (IL-6), C-reactive protein (CRP) and drug levels. LPS were determined by the QCL-1000 LAL assay, IL-6 by an enzymeimmunoassay, CRP by nephelometry and carbapenem levels by a microbiological assay. We did not find that carbapenems had any effect on the kinetics of LPS and CRP; IL-6 of group A was lower than group B at 72 and 84 hours. No correlation was observed between drug levels of any carbapenem and LPS, IL-6 or CRP. It is concluded that in septic patients with Gram-negative bacteremia administration of either imipenem or meropenem did not affect systemic endotoxemia. The above data support the safe administration of both carbapenems in patients with severe sepsis. |
| Databáze: | OpenAIRE |
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