GM1 ganglioside restores abnormal responses to acute thermal and mechanical stimuli in aged rats
| Autor: | Amy Lindsey, Virginia M. Goettl, Maria Hadjiconstantinou, Norton H. Neff |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Senescence
Male Pain Threshold Tail medicine.medical_specialty Aging Hot Temperature G(M1) Ganglioside Radiant heat Rats Sprague-Dawley Internal medicine Physical Stimulation Reflex medicine Reaction Time Animals Molecular Biology Hypoalgesia business.industry General Neuroscience Age Factors nervous system diseases Gm1 ganglioside Rats Endocrinology Allodynia Nociception Anesthesia Hyperalgesia Neurology (clinical) medicine.symptom business psychological phenomena and processes Tail flick test Developmental Biology |
| Zdroj: | Brain research. 858(2) |
| ISSN: | 0006-8993 |
| Popis: | We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3-5 months old) and aged (22-24 months old) male Sprague-Dawley rats were tested in the hot plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays. Compared to young rats, aged rats displayed longer latencies in the hot plate and the high-intensity tail flick assays (hypoalgesia), but there was no difference in the low-intensity tail flick assay. In addition, aged rats had decreased thresholds to mechanical stimuli produced by von Frey hairs compared with young rats (mechanical allodynia). Administration of GM1 ganglioside, 30 mg/kg, i.p., once daily for 30 days, to aged rats partially restored the responses in the hot plate and von Frey hair assays. GM1 had no effect on the altered responses in the tail flick test in aged rats, and in general, had no effect on any sensory modality tested in young rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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