RNAi: gene-silencing in therapeutic intervention

Autor:	Tony Giordano, David J Shuey, Daniel E McCallus
Rok vydání:	2003
Předmět:	Pharmacology Genetics fungi Cell RNA Genetic Therapy Biology Cell biology RNA silencing medicine.anatomical_structure Transcription (biology) RNA interference Drug Discovery Gene expression medicine Gene silencing Animals Humans RNA Interference Gene Silencing RNA Small Interfering Gene
Zdroj:	Drug discovery today. 7(20)
ISSN:	1359-6446
Popis:	Several rapidly developing RNA interference (RNAi) methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. As such, RNAi technology is currently being evaluated not only as an extremely powerful instrument for functional genomic analyses, but also as a potentially useful method to develop highly specific dsRNA based gene-silencing therapeutics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaa739fb801ed664a936d9cdd632dbb https://pubmed.ncbi.nlm.nih.gov/12546893 Zobrazit plný text záznamu Full Text from ScienceDirect